伴有胸腺和活化调节趋化因子（TARC）及免疫球蛋白E（IgE）水平升高的老年红皮病中的辅助性T细胞2极化
T helper 2 polarization in senile erythroderma with elevated levels of TARC and IgE.
作者信息
Nakano-Tahara Mayuko, Terao Mika, Nishioka Megumi, Kitaba Shun, Murota Hiroyuki, Katayama Ichiro
机构信息
Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan.
出版信息
Dermatology. 2015;230(1):62-9. doi: 10.1159/000366502. Epub 2015 Jan 8.
BACKGROUND
Some cases of senile erythroderma tend to be diagnosed as senile atopic dermatitis (AD) based on elevated levels of immunoglobulin E (IgE) and thymus and activation-regulated chemokine (TARC). However, there are few studies that describe the detailed characteristics of senile erythroderma and senile AD.
OBJECTIVE
We examined the association of erythroderma with AD.
METHODS
In this retrospective observational study, 68 patients over 65 years of age who presented with erythroderma at Osaka University Hospital were enrolled. Patient data were collected through medical records and descriptive statistics.
RESULTS
47% of the patients were classified as having idiopathic erythroderma and 53% as having secondary erythroderma. In both idiopathic and secondary senile erythroderma patients, serum IgE and TARC levels were elevated. 84% of idiopathic erythroderma patients fulfilled the Japanese Dermatological Associations criteria for AD; however, only 4 patients were finally definitely diagnosed with senile AD.
CONCLUSION
Many senile erythroderma patients showed AD-like symptoms due to T helper 2 polarization.
背景
一些老年红皮病病例因免疫球蛋白E（IgE）和胸腺与活化调节趋化因子（TARC）水平升高，往往被诊断为老年特应性皮炎（AD）。然而，很少有研究描述老年红皮病和老年AD的详细特征。
目的
我们研究了红皮病与AD之间的关联。
方法
在这项回顾性观察研究中，纳入了65岁以上在大阪大学医院出现红皮病的68例患者。通过病历收集患者数据并进行描述性统计。
结果
47%的患者被归类为特发性红皮病，53%为继发性红皮病。在特发性和继发性老年红皮病患者中，血清IgE和TARC水平均升高。84%的特发性红皮病患者符合日本皮肤病协会的AD标准；然而，最终只有4例患者被明确诊断为老年AD。
结论
许多老年红皮病患者由于辅助性T细胞2极化而表现出AD样症状。
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