Le Floc'h Caroline, Cheniti Ahsène, Connétable Sophie, Piccardi Nathalie, Vincenzi Colombina, Tosti Antonella
Laboratoires innéov, R&D, Asnières/Seine, France.
J Cosmet Dermatol. 2015 Mar;14(1):76-82. doi: 10.1111/jocd.12127. Epub 2015 Jan 8.
Female pattern hair loss is a frequent and distressing condition.
To evaluate vs. control, the effects on hair loss of a 6-month supplementation with specific omega 3&6 and antioxidants.
One hundred and twenty healthy female subjects participated in this 6-month, randomized, comparative study. The primary endpoint was the change in hair density evaluated on standardized photographs. Secondary endpoints included changes in telogen hair percentage and diameter distribution of anagen hair (>40 µm vs. ≤40 µm) measured by trichogram. Overall changes in hair density and diameter were also measured by trichometer and by subjects' self-assessment.
After 6 months of treatment, photograph assessment demonstrated a superior improvement in the supplemented group (P < 0.001). The telogen hair percentage was significantly (P < 0.001) reduced in the supplemented group. The proportion of nonvellus anagen hair (>40 µm) increased compared to the control group. The trichometer index increased in the supplemented group, while it decreased in the control group. A large majority of supplemented subjects reported a reduction in hair loss (89.9% of subjects at 6 months), as well as an improvement in hair diameter (86.1%) and hair density (87.3%).
A 6-month supplementation with omega 3&6 and antioxidants acts efficiently against hair loss in improving hair density and reducing the telogen percentage and the proportion of miniaturized anagen hair. Objectively measured improvements were confirmed by the subjects' perception of efficacy.
女性型脱发是一种常见且令人苦恼的病症。
评估与对照组相比,特定的ω-3和ω-6脂肪酸及抗氧化剂6个月补充疗法对脱发的影响。
120名健康女性受试者参与了这项为期6个月的随机对照研究。主要终点是通过标准化照片评估的头发密度变化。次要终点包括通过毛发计数法测量的休止期毛发百分比变化以及生长期毛发(>40微米与≤40微米)的直径分布变化。还通过毛发测量仪和受试者自我评估来测量头发密度和直径的总体变化。
治疗6个月后,照片评估显示补充剂组有更显著的改善(P < 0.001)。补充剂组的休止期毛发百分比显著降低(P < 0.001)。与对照组相比,非毳毛生长期毛发(>40微米)的比例增加。补充剂组的毛发测量仪指数增加,而对照组则下降。绝大多数补充剂组受试者报告脱发减少(6个月时89.9%的受试者),头发直径(86.1%)和头发密度(87.3%)也有所改善。
6个月的ω-3和ω-6脂肪酸及抗氧化剂补充疗法在改善头发密度、降低休止期毛发百分比和小型化生长期毛发比例方面对脱发有显著效果。受试者对疗效的感知证实了客观测量的改善。