Kim Jihee, An Jinho, Lee Yong-Kwang, Ha Gwangsu, Ban Hamin, Kong Hyunseok, Lee Heetae, Song Youngcheon, Lee Chong-Kil, Kim Sang Bum, Kim Kyungjae
Department of Pharmacy, College of Pharmacy, Sahmyook University, Seoul 01795, Republic of Korea.
Sturgeon Bio Co., Ltd., Cheongju 28581, Republic of Korea.
Pharmaceuticals (Basel). 2024 Aug 23;17(9):1112. doi: 10.3390/ph17091112.
Androgenetic alopecia is a common disease that occurs in both men and women. Several approved medications have been used to treat this condition, but they are associated with certain side effects. Therefore, use of extracts derived from natural products, such as Siberian sturgeon (), and the regulation of the gut microbiota have become important topics of research. Sturgeon is known for its high nutritional value and anti-inflammatory properties; however, its effects on androgenetic alopecia and gut microbiota remain uncharacterized. Here, we aimed to investigate whether solubilized sturgeon oil (SSO) promotes hair growth and regulates the gut microbiome. C57BL/6 mice were divided into four groups. Three groups received topical applications of distilled water, SSO, or minoxidil, and one group was orally administered SSO. Each treatment was administered over 4 weeks. Histopathological analysis revealed a significant increase in follicle number ( < 0.001) and follicle diameter ( < 0.05). Immunohistochemical analysis revealed upregulation of β-catenin and ERK-1, markers involved in hair growth-promoting pathways. Furthermore, microbiome analysis revealed that the reduced gut microbiota was negatively correlated with these markers. Our findings indicate that oral administration of SSO promotes hair growth and regulates the abundance of hair growth-promoting gut microbiota.
雄激素性脱发是一种常见于男性和女性的疾病。已有几种获批药物用于治疗该病症，但它们存在某些副作用。因此，使用源自天然产物的提取物，如西伯利亚鲟鱼（提取物），以及调节肠道微生物群已成为重要的研究课题。鲟鱼以其高营养价值和抗炎特性而闻名；然而，其对雄激素性脱发和肠道微生物群的影响仍未明确。在此，我们旨在研究溶解的鲟鱼油（SSO）是否能促进头发生长并调节肠道微生物组。将C57BL/6小鼠分为四组。三组分别局部涂抹蒸馏水、SSO或米诺地尔，一组口服SSO。每种处理持续4周。组织病理学分析显示毛囊数量显著增加（<0.001），毛囊直径增大（<0.05）。免疫组织化学分析显示β-连环蛋白和ERK-1上调，这两种标志物参与促进头发生长的途径。此外，微生物组分析表明肠道微生物群减少与这些标志物呈负相关。我们的研究结果表明，口服SSO可促进头发生长并调节促进头发生长的肠道微生物群的丰度。
