Hendrickson M, Shelby J, Sullivan J J, Saffle J R
University of Utah, Health Sciences Center, Salt Lake City.
J Burn Care Rehabil. 1989 Nov-Dec;10(6):494-8. doi: 10.1097/00004630-198911000-00006.
The effect of opioids (both exogenous and endogenous) on cell-mediated immune response in normal and thermally injured mice was evaluated with a delayed-type hypersensitivity assay. The administration of morphine sulfate to normal mice resulted in decreased delayed-type hypersensitivity response. This morphine sulfate-induced immunosuppression was prevented by concurrent treatment with the opioid antagonist, naloxone; however, naloxone alone did not alter immune response. Thermally injured mice had a suppressed delayed-type hypersensitivity response that was not further affected by morphine sulfate administration. In contrast, the immunosuppressive effects caused by burn injury, alone or in combination with the administration of morphine sulfate, were not observed in the presence of naloxone as measured by delayed-type hypersensitivity response. These results suggest that opioids depress cellular immune response and may play a role in immune dysfunction that follows thermal injury.
采用迟发型超敏反应试验评估了阿片类药物（外源性和内源性）对正常和热损伤小鼠细胞介导免疫反应的影响。给正常小鼠注射硫酸吗啡会导致迟发型超敏反应降低。阿片类拮抗剂纳洛酮同时治疗可预防硫酸吗啡诱导的免疫抑制；然而，单独使用纳洛酮不会改变免疫反应。热损伤小鼠的迟发型超敏反应受到抑制，硫酸吗啡给药对此没有进一步影响。相比之下，通过迟发型超敏反应测量发现，在纳洛酮存在的情况下，未观察到单独烧伤或烧伤与硫酸吗啡联合给药所引起的免疫抑制作用。这些结果表明，阿片类药物会抑制细胞免疫反应，并可能在热损伤后的免疫功能障碍中起作用。
