Hsieh You-Liang, Pai Peiying, Ho Tsung-Jung, Chung Li-Chin, Cheng Yi-Chang, Wu Chieh-Hsi, Fan Ming-Jen, Day Cecilia Hsuan, Shen Chia-Yao, Huang Chih-Yang
Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan, Republic of China.
Chin J Physiol. 2014 Dec 31;57(6):320-8. doi: 10.4077/CJP.2014.BAC261.
Hypercholesterol diets are the major causes of cardiac hypertrophy and various cardiac disorders. The purpose of this study is to evaluate the effects of garlic oil on cardiac hypertrophy induced by hypercholesterol diets. Golden Syrian hamsters were fed with 2% cholesterol or 2% cholesterol plus 1% garlic oil for 2 months. Heart architecture changes were measured by hematoxylin-eosin staining and the molecular mechanism was determined by western blotting. Garlic oil reduced whole-heart weight to bone weight ratio, and left ventricle weight to bone weight ratio in the cholesterol-fed group. Moreover, the garlic oil group showed significantly reduced interleukin-6, phosphorylated (p)-extracellular signal-regulated kinase-5, p-mitogen-activated protein kinase-5, calcineurin, nuclear transcription factor of nuclear factor of activated T-cells-3 and p-GATA binding protein 4 when compared with the cholesterol group. However, no changes were observed in gp-130, signal transducer and activator of transcription-3, p-P38 and p-Jun N-terminal kinases protein levels in all groups. The results show that garlic oil may be useful in the treatment of hypertrophy-associated cardiovascular diseases.
高胆固醇饮食是导致心脏肥大和各种心脏疾病的主要原因。本研究的目的是评估大蒜油对高胆固醇饮食诱导的心脏肥大的影响。将金黄叙利亚仓鼠分别喂食含2%胆固醇的饲料或含2%胆固醇加1%大蒜油的饲料，持续2个月。通过苏木精-伊红染色测量心脏结构变化，并通过蛋白质印迹法确定分子机制。大蒜油降低了胆固醇喂养组的全心重量与骨骼重量之比以及左心室重量与骨骼重量之比。此外，与胆固醇组相比，大蒜油组的白细胞介素-6、磷酸化（p）-细胞外信号调节激酶-5、p-丝裂原活化蛋白激酶-5、钙调神经磷酸酶、活化T细胞核因子-3的核转录因子和p-GATA结合蛋白4显著降低。然而，所有组的gp-130、信号转导和转录激活因子-3、p-P38和p-氨基末端激酶蛋白水平均未观察到变化。结果表明，大蒜油可能对治疗与肥大相关的心血管疾病有用。
