Mittal Deepak, Agarwala Sandeep, Yadav D K, Pramanik D D, Sharma M C, Bagga D
Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India.
Indian J Pediatr. 2015 Jun;82(6):549-52. doi: 10.1007/s12098-014-1667-1. Epub 2015 Jan 11.
To evaluate the presentation, treatment and outcome of testicular tumors in undescended testes (UDT) in boys below 5 y of age.
Case records of boys below 5 y of age, diagnosed to have germ cell tumors (GCT) in the UDT were reviewed.
Seven children in the age range of 05-54 mo (mean 26 mo) were included. While five of these 7 (71 %) presented with abdominal mass [one antenatally detected], 2 (29 %) were detected to have a GCT during orchiopexy. In three of these five with abdominal mass, the alpha-fetoprotein (αFP) was markedly elevated. Two of these three with elevated αFP were endodermal sinus tumors while the third was embryonal carcinoma. The 4th patient with an abdominal mass was diagnosed to have an immature teratoma (IMT) while the patient with antenatally diagnosed mass had a mature cystic teratoma (MT). Both the patients with incidentally detected mass during the orchiopexy had mature teratoma (MT). All the seven children are alive and disease free at last follow-up.
Though rare, boys with impalpable undescended testes may develop germ cell tumors early in childhood. These can be managed with chemotherapy and resection and have a good disease free outcome.
评估5岁以下男孩隐睾（UDT）中睾丸肿瘤的表现、治疗及预后。
回顾5岁以下被诊断为隐睾生殖细胞肿瘤（GCT）的男孩的病例记录。
纳入7名年龄在5个月至54个月（平均26个月）的儿童。这7名儿童中，5名（71%）表现为腹部肿块[1名在产前被检测到]，2名（29%）在睾丸固定术中被检测出患有生殖细胞肿瘤。在这5名有腹部肿块的儿童中，3名甲胎蛋白（αFP）显著升高。这3名αFP升高的儿童中，2名是内胚窦瘤，第3名是胚胎癌。第4名有腹部肿块的患者被诊断为未成熟畸胎瘤（IMT），而产前被检测到有肿块的患者患有成熟囊性畸胎瘤（MT）。在睾丸固定术中偶然检测到肿块的2名患者均患有成熟畸胎瘤（MT）。在最后一次随访时，所有7名儿童均存活且无疾病。
尽管罕见，但无法触及隐睾的男孩在儿童早期可能发生生殖细胞肿瘤。这些肿瘤可以通过化疗和手术切除进行治疗，且无病预后良好。
