Lee A Moses, Tai Lung-Hao, Zador Anthony, Wilbrecht Linda
Medical Scientist Training Program, University of California, San Francisco.
Department of Psychology, University of California, Berkeley.
Neuroscience. 2015 Jun 18;296:66-74. doi: 10.1016/j.neuroscience.2014.12.042. Epub 2015 Jan 7.
Decision making can be defined as the flexible integration and transformation of information from the external world into action. Recently, the development of novel genetic tools and new behavioral paradigms has made it attractive to study behavior of all kinds in rodents. By some perspectives, rodents are not an acceptable model for the study of decision making due to their simpler behavior often attributed to their less extensive cortical development when compared to non-human primates. We argue that decision making can be approached with a common framework across species. We review insights from comparative anatomy that suggest the expansion of cortical-striatal connectivity is a key development in evolutionary increases in behavioral flexibility. We briefly review studies that establish a role for corticostriatal circuits in integrative decision making. Finally, we provide an overview of a few recent, highly complementary rodent decision making studies using genetic tools, revealing with new cellular and temporal resolution how, when and where information can be integrated and compared in striatal circuits to influence choice.
决策可以被定义为将来自外部世界的信息灵活整合并转化为行动。最近，新型基因工具和新行为范式的发展使得研究啮齿动物的各种行为变得颇具吸引力。从某些角度来看，由于与非人类灵长类动物相比，啮齿动物的行为通常较为简单，这往往归因于它们不太广泛的皮质发育，因此它们不是研究决策的可接受模型。我们认为，可以用一个跨物种的通用框架来研究决策。我们回顾了比较解剖学的见解，这些见解表明皮质-纹状体连接的扩展是行为灵活性进化增加的关键发展。我们简要回顾了一些确立皮质纹状体回路在综合决策中作用的研究。最后，我们概述了最近一些使用基因工具的高度互补的啮齿动物决策研究，这些研究以新的细胞和时间分辨率揭示了纹状体回路中信息如何、何时以及何处可以被整合和比较以影响选择。
