Behavioural Neuroscience Laboratory, Brain & Mind Research Institute, University of Sydney, NSW 2006, Australia, and.
Discipline of Pharmacology, University of Sydney, NSW 2006, Australia.
J Neurosci. 2014 Jul 9;34(28):9196-201. doi: 10.1523/JNEUROSCI.0313-14.2014.
A cortical-basal ganglia network involving, particularly, the posterior region of dorsomedial striatum (DMS) has been implicated in the acquisition of goal-directed actions; however, no direct evidence of learning-related plasticity in this striatal region has been reported, nor is it known whether, or which, specific cell types are involved in this learning process. The striatum is primarily composed of two classes of spiny projection neurons (SPNs): the striatonigral and striatopallidal SPNs, which express dopamine D1 and D2 receptors, respectively. Here we establish that, in mice, the acquisition of goal-directed actions induced plasticity in both D1- and D2-SPNs specifically in the DMS and, importantly, that these changes were in opposing directions; after learning, AMPA/NMDA ratios were increased in D1-SPNs and reduced in the D2-SPNs in the DMS. Such opposing plasticity could provide the basis for rapidly rebiasing the control of task-specific actions, and its dysregulation could underlie disorders associated with striatal function.
一个涉及包括背内侧纹状体（DMS）后区在内的皮质-基底神经节网络，被认为与目标导向行为的获得有关；然而，目前还没有关于该纹状体区域与学习相关的可塑性的直接证据，也不知道哪些特定的细胞类型参与了这个学习过程。纹状体主要由两类棘突投射神经元（SPNs）组成：纹状体黑质和纹状体苍白球 SPNs，分别表达多巴胺 D1 和 D2 受体。在这里，我们确定在小鼠中，目标导向行为的获得诱导了 DMS 中 D1 和 D2-SPNs 的可塑性，重要的是，这些变化是相反的方向；学习后，DMS 中的 D1-SPNs 中的 AMPA/NMDA 比值增加，而 D2-SPNs 中的比值降低。这种相反的可塑性可以为快速重新调整任务特定动作的控制提供基础，其失调可能是与纹状体功能相关的疾病的基础。
