Lewis H, Wilkins M, Selwyn B, Yelland U, Griffith M, Bhoola K D
Department of Pharmacology, Medical Schools, University of Birmingham.
Adv Exp Med Biol. 1989;247A:281-6. doi: 10.1007/978-1-4615-9543-4_41.
Infusion of saline in healthy volunteers produced a significant rise in plasma atrial natriuretic peptide, which was accompanied by the urinary excretion of cyclic GMP and sodium. Although the time-course of cyclic GMP excretion almost mirrored that of plasma ANP, that of sodium showed sustained phase, indicating involvement of additional humoral regulators. ANP did not stimulate the excretion of enzymic or immunoreactive tissue kallikrein.
向健康志愿者输注生理盐水后，血浆心房利钠肽显著升高，同时伴有环磷酸鸟苷和钠的尿排泄增加。尽管环磷酸鸟苷排泄的时间进程几乎与血浆心房利钠肽的时间进程一致，但钠的排泄呈现持续阶段，表明存在其他体液调节因子的参与。心房利钠肽并未刺激酶性或免疫反应性组织激肽释放酶的排泄。
