Coors Marilyn E, Raymond Kristen M, McWilliams Shannon K, Hopfer Christian J, Mikulich-Gilbertson Susan K
Center for Bioethics and Humanities and Department of Psychiatry, University of Colorado Anschutz Medical Campus, 13080 E.19th Avenue B137, Aurora, CO 80045, USA.
Division of Substance Dependence University of Colorado Anschutz Medical Campus, 12469 East 17th Place F478, Aurora, CO 80045, USA.
Drug Alcohol Depend. 2015 Feb 1;147:272-5. doi: 10.1016/j.drugalcdep.2014.12.004. Epub 2014 Dec 15.
Perspectives of adolescent research participants regarding conflicts of interest (COIs) and their impact on trust in researchers have not been studied. This study evaluates views of adolescent patients in treatment for substance and conduct problems compared to controls enrolled in genomic addiction research.
Participants included 273 (190 patients, 83 controls) adolescents. Participants consented or assented (with parental consent) to have their genomic information deposited in a NIH biobank that shares information globally with qualified investigators. As part of that study, participants completed a COI survey. Endorsement of each COI item was analyzed with multiple logistic regressions, evaluating group, age, sex, ethnicity, and highest grade completed.
Patients and controls differed in gender, ethnicity and highest grade completed. In response to the survey, 38.4% of patients and 25.3% of controls "want to know" and 35.3% of patients and 37.3% of controls "might want to know" about COIs. Males were less likely to want/might want disclosure about COIs. Older patients were more likely to want disclosure about financial interests; patients were more likely to want disclosure about possible treatments; males were more likely to want information about monetary gains. Both groups requested between 1 paragraph and 1 page of information. Disclosure of COIs did not impact trust for most participants.
Adolescent patients and controls in this study want comparable information for disclosure of COIs including monetary gains, salary, publications, grants, and professional awards. Notably, the majority of patients and controls report that disclosure will not undermine trust in researchers.
青少年研究参与者对利益冲突（COI）及其对研究人员信任的影响的看法尚未得到研究。本研究评估了与参与基因组成瘾研究的对照组相比，正在接受物质和行为问题治疗的青少年患者的观点。
参与者包括273名青少年（190名患者，83名对照组）。参与者同意或在父母同意的情况下同意将其基因组信息存入美国国立卫生研究院生物样本库，该生物样本库与合格的研究人员全球共享信息。作为该研究的一部分，参与者完成了一项利益冲突调查。使用多元逻辑回归分析每个利益冲突项目的认可情况，评估组、年龄、性别、种族和最高学历。
患者和对照组在性别、种族和最高学历方面存在差异。在对调查的回应中，38.4%的患者和25.3%的对照组“想知道”，35.3%的患者和37.3%的对照组“可能想知道”利益冲突情况。男性不太可能希望/可能希望披露利益冲突。年龄较大的患者更有可能希望披露经济利益；患者更有可能希望披露可能的治疗方法；男性更有可能希望了解金钱收益信息。两组都要求提供1段到1页的信息。披露利益冲突对大多数参与者的信任没有影响。
本研究中的青少年患者和对照组希望获得类似的利益冲突披露信息，包括金钱收益、薪资、出版物、资助和专业奖项。值得注意的是，大多数患者和对照组报告称，披露不会损害对研究人员的信任。
