Perelshtein Ilana, Lipovsky Anat, Perkas Nina, Tzanov Tzanko, Аrguirova M, Leseva M, Gedanken Aharon
Department of Chemistry and Kanbar Laboratory for Nanomaterials, Bar-Ilan University Center for Advanced Materials and Nanotechnology, Ramat-Gan, Israel.
Universitat Politècnica de Catalunya, Edifici Gaia, Pg. Ernest Lluch/Rambla Sant Nebridi s/n, 08222 Terrassa, Spain.
Ultrason Sonochem. 2015 Jul;25:82-8. doi: 10.1016/j.ultsonch.2014.12.012. Epub 2015 Jan 5.
The ability to scale-up the sonochemical coating of medical textiles with antibacterial nanoparticles is demonstrated in the current paper. A roll-to-roll pilot installation to coat textiles was built taking into consideration the requirements of the sonochemical process. A long-run experiment was conducted in which 2500 m of fabric were coated with antibacterial ZnO nanoparticles (NPs). The metal oxide NPs were deposited from an ethanol:water solution. In this continuous process a uniform concentration of coated NPs over the length/width of the fabric was achieved. The antibacterial efficiency of the sonochemically-coated textiles was validated in a hospital environment by a reduction in the occurrence of nosocomial infections. NP-coated bed sheets, patient gowns, pillow cover, and bed covers were used by 21 patients. For comparison 16 patients used regular textiles. The clinical data indicated the reduced occurrence of hospital-acquired infections when using the metal oxide NP-coated textiles. In order to reduce the cost of the coating process and considering safety issues during manufacturing, the solvent (ethanol:water) (9:1 v:v) used for the long-run experiment, was replaced by water. Although lesser amounts of ZnO NPs were deposited on the fabric in the water-based process the antibacterial activity of the textiles was preserved due to the smaller size of the particles.
本文展示了扩大医用纺织品与抗菌纳米颗粒的声化学涂层处理规模的能力。考虑到声化学过程的要求，搭建了一个用于纺织品涂层的卷对卷中试装置。进行了一项长期实验，用抗菌氧化锌纳米颗粒（NPs）对2500米织物进行了涂层处理。金属氧化物纳米颗粒从乙醇：水溶液中沉积。在这个连续过程中，在织物的长度/宽度上实现了涂层纳米颗粒的均匀浓度。通过减少医院感染的发生率，在医院环境中验证了声化学涂层纺织品的抗菌效率。21名患者使用了纳米颗粒涂层的床单、病人袍、枕套和床罩。作为对照，16名患者使用了普通纺织品。临床数据表明，使用金属氧化物纳米颗粒涂层纺织品时，医院获得性感染的发生率降低。为了降低涂层工艺成本并考虑制造过程中的安全问题，将长期实验中使用的溶剂（乙醇：水）（9:1 v:v）换成了水。尽管在水基工艺中沉积在织物上的氧化锌纳米颗粒数量较少，但由于颗粒尺寸较小，纺织品的抗菌活性得以保留。
