Arunachalam Kannappan, Pandurangan Poonguzhali, Shi Chunlei, Lagoa Ricardo
MOST-USDA Joint Research Center for Food Safety, Department of Food Science and Technology, School of Agriculture and Biology, and State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Minhang, Shanghai 200240, China.
Department of Microbiology, M.R. Government Arts College, Mannargudi, Coimbatore 614001, Tamil Nadu, India.
Pharmaceutics. 2023 Jan 17;15(2):310. doi: 10.3390/pharmaceutics15020310.
is a versatile pathogen known to cause hospital- and community-acquired, foodborne, and zoonotic infections. The clinical infections by cause an increase in morbidity and mortality rates and treatment costs, aggravated by the emergence of drug-resistant strains. As a multi-faceted pathogen, it is imperative to consolidate the knowledge on its pathogenesis, including the mechanisms of virulence regulation, development of antimicrobial resistance, and biofilm formation, to make it amenable to different treatment strategies. Nanomaterials provide a suitable platform to address this challenge, with the potential to control intracellular parasitism and multidrug resistance where conventional therapies show limited efficacy. In a nutshell, the first part of this review focuses on the impact of on human health and the role of virulence factors and biofilms during pathogenesis. The second part discusses the large diversity of nanoparticles and their applications in controlling infections, including combination with antibiotics and phytochemicals and the incorporation of antimicrobial coatings for biomaterials. Finally, the limitations and prospects using nanomaterials are highlighted, aiming to foster the development of novel nanotechnology-driven therapies against multidrug-resistant
是一种多用途病原体，已知可引起医院获得性、社区获得性、食源性和人畜共患病感染。由其引起的临床感染会导致发病率、死亡率和治疗成本增加，耐药菌株的出现更是加剧了这种情况。作为一种多方面的病原体，巩固对其发病机制的认识至关重要，包括毒力调节机制、抗菌耐药性的发展以及生物膜形成，以便使其适用于不同的治疗策略。纳米材料提供了一个应对这一挑战的合适平台，有可能在传统疗法疗效有限的情况下控制细胞内寄生和多重耐药性。简而言之，本综述的第一部分重点关注其对人类健康的影响以及毒力因子和生物膜在发病机制中的作用。第二部分讨论了纳米颗粒的多样性及其在控制感染方面的应用，包括与抗生素和植物化学物质的联合使用以及生物材料抗菌涂层的应用。最后，强调了使用纳米材料的局限性和前景，旨在促进新型纳米技术驱动的抗多重耐药性治疗方法的发展
