The textile industry can benefit from nanotechnology as new properties are conferred on functionalized nanotextiles beyond what a fabric can traditionally offer. These properties include extermination of microorganisms by nanotextiles to curtail their growth and dissemination in the environment and in healthcare facilities. The emergence and thriving of multi-drug resistance (MDR) phenomenon among microbes are threats at achieving good health and well-being (goal 3) of sustainable development goals (SDG) of UN. In addition, MDR strains emerge at a higher rate than the frequency of discovery and production of potent antimicrobial drugs. Therefore, there is need for innovative approach to tackle MDR. Among recent innovations is functionalization of textiles with metal nanoparticles to kill microorganisms. This paper explores strategies in nanotextile production to combat emerging diseases in the 21 century. We discussed different nanotextiles with proven antimicrobial activities, and their applications as air filters, sportswear, personal wears, nose masks, health care and medical fabrics. This compendium highlights frontiers of applications of antimicrobial nanotextiles that can extend multidisciplinary research endeavours towards achieving good health and well-being. Until now, there exists no review on exploitation of nanotextiles to combat MDR pathogens as included in this report.