Coleman R E, Edman J D, Semprevivo L H
Department of Entomology, University of Massachusetts, Amherst 01003.
Ann Trop Med Parasitol. 1989 Aug;83(4):339-44. doi: 10.1080/00034983.1989.11812354.
BALB/c mice were infected with Leishmania mexicana amazonensis and/or Plasmodium yoelii in order to determine the impact of multiple parasitic infection on the efficacy of chemotherapeutic agents. Uninfected, P. yoelii-infected, L.m. amazonensis-infected, and L.m. amazonensis and P. yoelii-infected mice were inoculated with cimetidine (80 mg kg-1 day-1) or pentostam (200 mg kg-1 day-1) once a day for an initial 20-day period, and once a week thereafter. Leishmania mexicana amazonensis lesion development and P. yoelii parasitaemia were the criteria used to assay disease severity. Mice infected with both P. yoelii and L.m. amazonensis developed more severe disease than did animals infected with either parasite alone. Cimetidine and pentostam each slowed the development of L.m. amazonensis in animals infected with only that parasite and in animals infected with both P. yoelli and L.m. amazonensis. However, mice treated with pentostam developed more severe P. yoelii infections than did control animals, whereas cimetidine significantly reduced P. yoelii parasitaemia in all instances.
为了确定多重寄生虫感染对化疗药物疗效的影响，将BALB/c小鼠感染墨西哥利什曼原虫亚马逊亚种和/或约氏疟原虫。未感染、感染约氏疟原虫、感染墨西哥利什曼原虫亚马逊亚种以及同时感染墨西哥利什曼原虫亚马逊亚种和约氏疟原虫的小鼠，在最初20天每天接种西咪替丁（80毫克/千克/天）或喷他脒（200毫克/千克/天），之后每周接种一次。以墨西哥利什曼原虫亚马逊亚种病变发展和约氏疟原虫血症作为评估疾病严重程度的标准。同时感染约氏疟原虫和墨西哥利什曼原虫亚马逊亚种的小鼠，比仅感染其中一种寄生虫的动物病情更严重。西咪替丁和喷他脒均减缓了仅感染墨西哥利什曼原虫亚马逊亚种的动物以及同时感染约氏疟原虫和墨西哥利什曼原虫亚马逊亚种的动物体内该寄生虫的发展。然而，接受喷他脒治疗的小鼠比对照动物的约氏疟原虫感染更严重，而西咪替丁在所有情况下均显著降低了约氏疟原虫血症。
