Coleman R E, Edman J D, Semprevivo L H
Department of Entomology, University of Massachusetts, Amherst 01003.
Exp Parasitol. 1988 Apr;65(2):269-76. doi: 10.1016/0014-4894(88)90131-2.
Effect of concomitant malaria on cutaneous leishmaniasis. Development of lesions in a Leishmania-susceptible (BALB/c) strain of mouse. Experimental Parasitology 65, 269-276. Symptoms of human leishmaniasis vary greatly, ranging from cryptic infections to cases with fatal sequelae. Factors regulating the severity of the disease are largely undetermined. Malaria coincides geographically with leishmaniasis in many areas and the immunosuppressive effects of malaria are well documented. It is therefore plausible that malaria could enhance the course of concomitant leishmaniasis. Interactions between Leishmania mexicana and Plasmodium yoelii were examined in BALB/c mice. Percentage of blood cells infected with P. yoelii and diameter of footpad lesions caused by L. mexicana were the criteria used to assay for disease severity. L. mexicana and P. yoelii infections were each significantly enhanced in dually infected mice when compared to mice infected with either parasite alone. Mortality rates due to the normally nonlethal P. yoelii were high during concurrent infections.
疟疾并发对皮肤利什曼病的影响。利什曼原虫易感（BALB/c）品系小鼠病变的发展。《实验寄生虫学》65卷，第269 - 276页。人类利什曼病的症状差异很大，从隐匿性感染到伴有致命后遗症的病例都有。调节该病严重程度的因素在很大程度上尚未确定。在许多地区，疟疾在地理上与利什曼病重合，而且疟疾的免疫抑制作用有充分的文献记载。因此，疟疾可能会加重并发利什曼病的病程这一推测是合理的。在BALB/c小鼠中研究了墨西哥利什曼原虫与约氏疟原虫之间的相互作用。感染约氏疟原虫的血细胞百分比以及由墨西哥利什曼原虫引起的足垫病变直径是用于测定疾病严重程度的标准。与单独感染任一寄生虫的小鼠相比，双重感染小鼠体内的墨西哥利什曼原虫和约氏疟原虫感染均显著增强。在同时感染期间，通常无致死性的约氏疟原虫导致的死亡率很高。
