Coleman R E, Edman J D, Semprevivo L H
Department of Entomology, University of Massachusetts, Amherst 01003.
Am J Trop Med Hyg. 1988 Dec;39(6):540-4. doi: 10.4269/ajtmh.1988.39.540.
We examined the effect of concurrent infection with Plasmodium yoelii and Leishmania mexicana amazonensis on the course of each disease in leishmania resistant C57Bl/6 mice. P. yoelii parasitemia was greatly enhanced when L. m. amazonensis was inoculated 2 days, 3 weeks, or 12 weeks prior to the malaria. Lesions due to L. m. amazonensis were enhanced in mice concomitantly infected with P. yoelii compared to mice infected with L. m. amazonensis only. Metastatic L. m. amazonensis lesions developed in mice infected with P. yoelii and L. m. amazonensis, but never in mice only infected with L. m. amazonensis.
我们研究了约氏疟原虫与亚马逊利什曼原虫同时感染对利什曼原虫抗性C57Bl/6小鼠体内每种疾病病程的影响。当在感染疟疾前2天、3周或12周接种亚马逊利什曼原虫时，约氏疟原虫血症会显著增强。与仅感染亚马逊利什曼原虫的小鼠相比，同时感染约氏疟原虫的小鼠因亚马逊利什曼原虫引起的病变有所增强。在感染约氏疟原虫和亚马逊利什曼原虫的小鼠中出现了转移性亚马逊利什曼原虫病变，但仅感染亚马逊利什曼原虫的小鼠从未出现过这种情况。
