环境在非嵌入剂与Z-DNA相互作用中的作用。

Role of the environment in the interaction of nonintercalators with Z-DNA.

作者信息

Rao K E, Ramesh N, Choudhury D, Brahmachari S K, Sasisekharan V

机构信息

Molecular Biophysics Unit, Indian Institute of Science, Bangalore.

出版信息

J Biomol Struct Dyn. 1989 Oct;7(2):335-45. doi: 10.1080/07391102.1989.10507776.

DOI:10.1080/07391102.1989.10507776

PMID:2557862

Abstract

Interaction of the DNA binding nonintercalators Netropsin, Distamycin and the mPD derivative with Z-DNA has been studied. It has been found that environmental factors like the solvent and added cations significantly modulate the interaction of these ligands with Z-DNA. However no definite Z to B transition in presence of these ligands was found in any case, in contrast to previously reported results (Ch. Zimmer, C. Marck and W. Guschlbauer, FEBS Lett. 154, 156-160 (1983)).

摘要

已经研究了DNA结合非嵌入剂纺锤菌素、偏端霉素和mPD衍生物与Z-DNA的相互作用。已发现，诸如溶剂和添加的阳离子等环境因素会显著调节这些配体与Z-DNA的相互作用。然而，与先前报道的结果（Ch.齐默尔、C.马克和W.古施尔鲍尔，《欧洲生物化学学会联合会快报》154, 156 - 160 (1983)）相反，在任何情况下，在这些配体存在时均未发现明确的Z型向B型转变。