Geng G Y, Liu H L, Zhao Y J, Wu L, Mao L, Ba N
Department of Cardiology, People's Hospital of Zhengzhou, Zhengzhou, China.
Genet Mol Res. 2015 Sep 25;14(3):11488-94. doi: 10.4238/2015.September.25.15.
A case-control study was conducted to investigate the association between genetic variants of IL-17A rs2275913 and IL-17F rs763780 and the development of coronary artery disease (CAD) in a Chinese population. A total of 306 individuals with CAD and 306 unaffected individuals were enrolled from the Zhengzhou People's Hospital between May 2012 and May 2014. The IL-17A rs2275913 and IL-17F rs763780 genes were genotyped by polymerase chain reaction combined with a restriction fragment length polymorphism (PCR-RFLP). Logistic regression analysis revealed that individuals with the AA genotype of rs2275913 were associated with increased risk of CAD, compared to those with the GG genotype in a codominant model [adjusted odds ratio (OR) = 1.96; 95% confidence interval (CI) = 1.10-3.53]. On the other hand, the AA genotype of rs2275913 was correlated with moderately increased risk of CAD compared to the GG + GA genotype (adjusted OR = 1.76; 95%CI = 1.02-3.07) in a recessive model. However, no significant differences were observed between polymorphisms at the IL-17F rs763780 locus and CAD risk, in codominant, dominant, and recessive models. In conclusion, the results of our study suggested that the IL-17A rs2275913 polymorphism may affect the development of CAD; however, no significant association was observed between the IL-17F rs763780 polymorphism and risk of CAD.
开展了一项病例对照研究，以调查白细胞介素-17A（IL-17A）rs2275913和白细胞介素-17F（IL-17F）rs763780的基因变异与中国人群冠状动脉疾病（CAD）发生之间的关联。2012年5月至2014年5月期间，从郑州市人民医院招募了306例CAD患者和306例未受影响的个体。采用聚合酶链反应结合限制性片段长度多态性（PCR-RFLP）对IL-17A rs2275913和IL-17F rs763780基因进行基因分型。逻辑回归分析显示，在共显性模型中，rs2275913的AA基因型个体与CAD风险增加相关，与GG基因型个体相比[调整优势比（OR）=1.96；95%置信区间（CI）=1.10-3.53]。另一方面，在隐性模型中，与GG+GA基因型相比，rs2275913的AA基因型与CAD风险适度增加相关（调整OR=1.76；95%CI=1.02-3.07）。然而，在共显性、显性和隐性模型中，未观察到IL-17F rs763780位点多态性与CAD风险之间存在显著差异。总之，我们的研究结果表明，IL-17A rs2275913多态性可能影响CAD的发生；然而，未观察到IL-17F rs763780多态性与CAD风险之间存在显著关联。
