Department of Dermatology, Preventive Medicine, and Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, Ill.
Department of Preventive Medicine and Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Ill.
J Allergy Clin Immunol. 2015 Mar;135(3):721-8.e6. doi: 10.1016/j.jaci.2014.11.023. Epub 2015 Jan 8.
Eczema is associated with high rates of sleep disturbance and quality-of-life impairment. These factors might have a negative impact on psychosocial development and behavior and could increase cardiovascular risk.
We sought to determine whether adults with eczema have increased cardiovascular risk factors.
We analyzed data for 27,157 and 34,525 adults aged 18 to 85 years from the 2010 and 2012 National Health Interview Survey.
Adults with eczema had higher odds of ever smoking 100 cigarettes in their lifetime (survey logistic regression; adjusted odds ratio [aOR], 1.32; 95% CI, 1.18-1.47) and current smoking history (aOR, 1.28; 95% CI, 1.12-1.45), with significantly younger age of onset (survey linear regression; adjusted β, -0.58; 95% CI, -0.95 to -0.21). Eczema was also associated with greater odds of ever drinking 12 or more alcoholic beverages annually (aOR, 1.16; 95% CI, 1.03-1.31), including current intake of moderate (aOR, 1.33; 95% CI, 1.09-1.62) and heavier (aOR, 1.58; 95% CI, 1.23-2.03) amounts. Adults with a history of eczema had lower odds of daily vigorous activity (aOR, 0.79; 95% CI, 0.63-0.99) and lower frequency of vigorous activity in the past week (adjusted β, -0.46; 95% CI, -0.72 to -0.21) than did adults without a history of eczema. Those with eczema had a higher body mass index than did those without eczema (adjusted β, 0.86; 95% CI, 0.37-1.36), particularly a body mass index of 35 or more (aOR, 1.54; 95% CI, 1.16-2.05), and higher odds of hypertension (aOR, 1.48; 95% CI, 1.18-1.85), hypertension on 2 visits (aOR, 1.56; 1.22-1.99), and lifetime prediabetes (aOR, 1.71; 95% CI, 1.19-2.45). Finally, there were significant interactions between eczema and sleep disturbances such that eczema associated with fatigue, daytime sleepiness, or insomnia was associated with even higher odds of obesity, hypertension, hypertension on 2 visits, prediabetes, diabetes, and high cholesterol than eczema alone.
We found that eczema in adults is a marker for cardiovascular risk, emphasizing the importance of behavioral modification and perhaps more aggressive interventions to better manage eczema.
湿疹与睡眠障碍和生活质量受损的高发病率有关。这些因素可能对社会心理发展和行为产生负面影响，并可能增加心血管风险。
我们旨在确定患有湿疹的成年人是否存在更高的心血管危险因素。
我们分析了 2010 年和 2012 年全国健康访谈调查中 18 至 85 岁的 27157 名和 34525 名成年人的数据。
患有湿疹的成年人终生吸烟 100 支香烟的可能性更高（调查逻辑回归；调整后的优势比[OR]，1.32；95%CI，1.18-1.47）和当前吸烟史（OR，1.28；95%CI，1.12-1.45），发病年龄明显更小（调查线性回归；调整后的β，-0.58；95%CI，-0.95 至-0.21）。湿疹也与更高的可能性有关，即每年饮用 12 杯或更多的含酒精饮料（OR，1.16；95%CI，1.03-1.31），包括目前摄入中等量（OR，1.33；95%CI，1.09-1.62）和更大量（OR，1.58；95%CI，1.23-2.03）。有湿疹病史的成年人每天进行剧烈运动的可能性较低（OR，0.79；95%CI，0.63-0.99），过去一周进行剧烈运动的频率也较低（调整后的β，-0.46；95%CI，-0.72 至-0.21），而没有湿疹病史的成年人则较低。有湿疹的成年人的体重指数高于没有湿疹的成年人（调整后的β，0.86；95%CI，0.37-1.36），尤其是体重指数为 35 或更高（OR，1.54；95%CI，1.16-2.05），以及高血压的可能性更高（OR，1.48；95%CI，1.18-1.85），两次就诊时高血压（OR，1.56；1.22-1.99），以及终身前驱糖尿病（OR，1.71；95%CI，1.19-2.45）。最后，湿疹和睡眠障碍之间存在显著的相互作用，以至于与疲劳、白天嗜睡或失眠相关的湿疹与肥胖、高血压、两次就诊时的高血压、前驱糖尿病、糖尿病和高胆固醇的可能性更高，而不仅仅是湿疹。
我们发现，成年人的湿疹是心血管风险的一个标志，这强调了行为改变的重要性，也许更积极的干预措施可以更好地治疗湿疹。
