Siegfried B, de Souza R L
Institute of Pharmacology, University of Zurich, Switzerland.
Eur J Pharmacol. 1989 Sep 13;168(2):239-42. doi: 10.1016/0014-2999(89)90570-0.
Microinjections of N-methyl-D-aspartate (NMDA, 0.1 and 1.0 nmol) into the periaqueductal grey (PAG) of the mouse resulted in potential antinociception. In a social conflict situation, attacked mice exhibited a marked analgesia that was prevented by prior injection of the competitive NMDA antagonist, AP-7 (2.0 nmol) or naloxone (6.0 nmol) into the PAG and also by i.p. injection of the non-competitive NMDA antagonist, MK-801 (33 nmol). These results demonstrate that NMDA receptors are involved in endogenous analgesic mechanisms activated by stress.
向小鼠中脑导水管周围灰质（PAG）微量注射N-甲基-D-天冬氨酸（NMDA，0.1和1.0纳摩尔）可产生潜在的镇痛作用。在社会冲突情境中，受攻击的小鼠表现出明显的镇痛作用，预先向PAG注射竞争性NMDA拮抗剂AP-7（2.0纳摩尔）或纳洛酮（6.0纳摩尔）以及腹腔注射非竞争性NMDA拮抗剂MK-801（33纳摩尔）均可阻止这种镇痛作用。这些结果表明，NMDA受体参与了由应激激活的内源性镇痛机制。
