Carbone Mario, Della Ferrera Francesco, Carbone Lucio, Gatti Gaia, Carrozzo Marco
Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy.
Private Practice, Turin, Italy.
Case Rep Dent. 2014;2014:413162. doi: 10.1155/2014/413162. Epub 2014 Dec 16.
Numb chin syndrome is a rare sensory neuropathy of the mental nerve characterized by numbness, hypoesthesia, paraesthesia, and very rarely pain. Dental causes, especially iatrogenic ones, maxillofacial trauma, or malignant neoplasm are etiologic factors for this rare syndrome. Many malignant and metastatic neoplasms are causing this syndrome, like primary osteosarcoma, squamous cell carcinoma, and mandibular metastasis of primary carcinoma of breast, lung, thyroid, kidney, prostate, and nasopharynx. Haematological malignancies like acute lymphocytic leukaemia, Hodgkin and non-Hodgkin lymphoma, and myeloma can cause this neuropathy. The authors report a case of a 71-year-old woman in which the numb chin syndrome was the first symptom of the diffuse large B-cell lymphoma, which caused infiltration and reabsorption of the alveolar ridge and lower mandibular cortex. A biopsy of the mass was performed on fragments of tissue collected from the mandibular periosteum, medullary and cortical mandibular bone, and inferior alveolar nerve.
颏部麻木综合征是一种罕见的颏神经感觉神经病，其特征为麻木、感觉减退、感觉异常，极少出现疼痛。牙科病因，尤其是医源性病因、颌面创伤或恶性肿瘤是这种罕见综合征的病因。许多恶性和转移性肿瘤可导致该综合征，如原发性骨肉瘤、鳞状细胞癌以及乳腺癌、肺癌、甲状腺癌、肾癌、前列腺癌和鼻咽癌的下颌骨转移。血液系统恶性肿瘤如急性淋巴细胞白血病、霍奇金淋巴瘤和非霍奇金淋巴瘤以及骨髓瘤也可导致这种神经病。作者报告了一例71岁女性病例，其中颏部麻木综合征是弥漫性大B细胞淋巴瘤的首发症状，该淋巴瘤导致牙槽嵴和下颌骨皮质浸润及重吸收。对从下颌骨骨膜、下颌骨骨髓和皮质骨以及下牙槽神经采集的组织碎片进行了肿块活检。
