Babikir Mona M, Mohamed Shehab F, Nashwan Abdulqadir J, Mudawi Deena S, Purayil Saleema C, Abdelrazek Mohamed Talaat, Ahmed Khalid E, Yassin Mohamed A
Department of Medical Education, Hamad Medical Corporation, Doha, Qatar.
Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research (NCCCR), Hamad Medical Corporation, Doha, Qatar.
Am J Case Rep. 2020 Mar 3;21:e920117. doi: 10.12659/AJCR.920117.
BACKGROUND Numb chin syndrome is a rare and under diagnosed neuropathy of the inferior alveolar branch of the trigeminal nerve usually causing a lower lip and chin anesthesia or paresthesia. The syndrome is commonly associated with broad-spectrum malignant and non-malignant conditions. CASE REPORT Here we report a case of a 30-year-old male who presented with numb chin syndrome in the form of jaw pain, paresthesia, and hypoesthesia of the mental area as the presenting symptoms of acute of myeloid leukemia with t(8;21) treated with (3+7) protocol (3 days anthracycline+7 days cytarabine). The pain and paresthesia improved but hypothesia persisted. CONCLUSIONS Acute myeloid leukemia is one of the most serious causes of numb chin syndrome which should not be overlooked.
颏部麻木综合征是一种罕见且诊断不足的三叉神经下颌支神经病变，通常导致下唇和颏部麻木或感觉异常。该综合征常与多种恶性和非恶性疾病相关。病例报告：我们在此报告一例30岁男性，以颌部疼痛、感觉异常和颏部感觉减退为表现形式的颏部麻木综合征，这是急性髓系白血病伴t(8;21)采用(3+7)方案（3天蒽环类药物+7天阿糖胞苷）治疗的首发症状。疼痛和感觉异常有所改善，但感觉减退仍持续存在。结论：急性髓系白血病是颏部麻木综合征最严重的病因之一，不应被忽视。
