Olsen Meghan P, Mitchell Allen O, Miles Edward F
Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Division of Otolaryngology, Department of Surgery, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708, USA.
Case Rep Oncol Med. 2014;2014:345128. doi: 10.1155/2014/345128. Epub 2014 Dec 14.
Salivary gland cancers are rare and represent approximately 5% of all head and neck cancers and only 0.3% of all malignancies. The majority (75%) of salivary gland tumors occur in the parotid gland, and while benign lesions are more common, mucoepidermoid carcinoma (MEC) makes up 40-50% of malignant parotid gland tumors. No randomized controlled trials exist regarding the role of adjuvant radiation for patients who undergo surgical resection of low-grade MECs. Herein, we report two cases of successful postoperative radiation therapy in low-grade, pT2N0 MEC of the parotid gland. The role of adjuvant radiation therapy for patients with MEC of the parotid gland is based on data from institution reviews and lacks data from randomized controlled trials. Per our review of the literature, the pathological findings of positive surgical margins and/or perineural invasion in two patients with low-grade MEC of the parotid gland warranted adjuvant radiation for improved local control after partial parotidectomy. Both patients tolerated postoperative radiation therapy with only mild side effects and, at last follow-up, five years after completion of therapy, had no clinical or radiographic evidence of either local recurrence or distant metastasis.
唾液腺癌较为罕见，约占所有头颈癌的5%，仅占所有恶性肿瘤的0.3%。大多数（75%）唾液腺肿瘤发生在腮腺，虽然良性病变更为常见，但黏液表皮样癌（MEC）占腮腺恶性肿瘤的40 - 50%。对于接受低级别MEC手术切除的患者，目前尚无关于辅助放疗作用的随机对照试验。在此，我们报告两例腮腺低级别、pT2N0 MEC术后放疗成功的病例。腮腺MEC患者辅助放疗的作用基于机构回顾的数据，缺乏随机对照试验的数据。根据我们对文献的回顾，两名腮腺低级别MEC患者手术切缘阳性和/或神经周围浸润的病理结果表明，在部分腮腺切除术后进行辅助放疗有助于改善局部控制。两名患者均耐受术后放疗，仅出现轻微副作用，在治疗完成五年后的最后一次随访中，没有局部复发或远处转移的临床或影像学证据。
