使用含活性酯聚合物简便制备纳米凝胶
Facile Preparation of Nanogels Using Activated Ester Containing Polymers.
作者信息
Zhuang Jiaming, Jiwpanich Siriporn, Deepak V D, Thayumanavan S
机构信息
Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003.
出版信息
ACS Macro Lett. 2011 Dec 13;1(1):175-179. doi: 10.1021/mz200123f.
Abstract
A facile methodology to prepare water-dispersible nanogels based on pentafluorophenyl acrylate and polyethylene glycol methacrylate random copolymer and diamine cross-linkers has been developed. Cross-linking reaction was characterized by FTIR and F NMR. We show that those nanogels : () are water-dispersible; () can conveniently encapsulate lipophilic guest molecules; () can be prepared with different nanosizes; () are engineered to allow for surface decoration with additional functional groups.
摘要
已经开发出一种基于丙烯酸五氟苯酯和聚乙二醇甲基丙烯酸酯无规共聚物以及二胺交联剂制备水分散性纳米凝胶的简便方法。通过傅里叶变换红外光谱（FTIR）和氟核磁共振（F NMR）对交联反应进行了表征。我们表明，那些纳米凝胶：（i）是水分散性的；（ii）能够方便地包封亲脂性客体分子；（iii）可以制备成不同的纳米尺寸；（iv）经过设计可以用额外的官能团进行表面修饰。
相似文献
1
Facile Preparation of Nanogels Using Activated Ester Containing Polymers.使用含活性酯聚合物简便制备纳米凝胶
ACS Macro Lett. 2011 Dec 13;1(1):175-179. doi: 10.1021/mz200123f.
2
Erratum: Preparation of Poly(pentafluorophenyl acrylate) Functionalized SiO2 Beads for Protein Purification.勘误：用于蛋白质纯化的聚（丙烯酸五氟苯酯）功能化二氧化硅微珠的制备
J Vis Exp. 2019 Apr 30(146). doi: 10.3791/6328.
3
Cascade post-polymerization modification of single pentafluorophenyl ester-bearing homopolymer as a facile route to redox-responsive nanogels.通过单五氟苯酯封端均聚物的级联聚合后修饰，为氧化还原响应性纳米凝胶提供了一种简便的方法。
J Colloid Interface Sci. 2017 Sep 1;501:94-102. doi: 10.1016/j.jcis.2017.04.030. Epub 2017 Apr 12.
4
Dual-reactive nanogels for orthogonal functionalization of hydrophilic shell and amphiphilic network.双重响应性纳米凝胶用于亲水壳层和两亲网络的正交功能化。
Soft Matter. 2022 Apr 6;18(14):2858-2871. doi: 10.1039/d2sm00116k.
5
Covalent Cross-Linking as a Strategy to Prepare Water-Dispersible Chitosan Nanogels.共价交联作为制备水分散性壳聚糖纳米凝胶的一种策略。
Polymers (Basel). 2023 Jan 13;15(2):434. doi: 10.3390/polym15020434.
6
Synthesis of Anionic Nanogels for Selective and Efficient Enzyme Encapsulation.用于选择性高效酶包封的阴离子纳米凝胶的合成
Langmuir. 2022 Mar 15;38(10):3234-3243. doi: 10.1021/acs.langmuir.1c03325. Epub 2022 Feb 25.
7
Surface-functionalizable polymer nanogels with facile hydrophobic guest encapsulation capabilities.具有易于疏水性客体包封能力的表面功能化聚合物纳米凝胶。
J Am Chem Soc. 2010 Jun 23;132(24):8246-7. doi: 10.1021/ja102316a.
8
Synthesis of Nanogel-Protein Conjugates.纳米凝胶-蛋白质缀合物的合成
Polym Chem. 2013 Apr 21;4(8):2464-2469. doi: 10.1039/C3PY00085K.
9
Water dispersible siloxane nanogels: a novel technique to control surface characteristics and drug release kinetics.水分散性硅氧烷纳米凝胶：一种控制表面特性和药物释放动力学的新技术。
J Mater Chem B. 2016 Aug 21;4(31):5299-5307. doi: 10.1039/c6tb01002d. Epub 2016 Jul 25.
10
"Clickable" Nanogels via Thermally Driven Self-Assembly of Polymers: Facile Access to Targeted Imaging Platforms using Thiol-Maleimide Conjugation.通过热驱动聚合物自组装制备“点击型”纳米凝胶：利用巯基-马来酰亚胺点击化学反应制备靶向成像平台。
Biomacromolecules. 2017 Feb 13;18(2):490-497. doi: 10.1021/acs.biomac.6b01576. Epub 2017 Jan 25.
引用本文的文献
1
Structural Determinants of Stimuli-Responsiveness in Amphiphilic Macromolecular Nano-assemblies.两亲性大分子纳米组装体中刺激响应性的结构决定因素
Prog Polym Sci. 2024 Jan;148. doi: 10.1016/j.progpolymsci.2023.101765. Epub 2023 Dec 9.
2
Nanogels as novel drug nanocarriers for CNS drug delivery.纳米凝胶作为用于中枢神经系统药物递送的新型药物纳米载体。
Front Mol Biosci. 2023 Aug 8;10:1232109. doi: 10.3389/fmolb.2023.1232109. eCollection 2023.
3
Thiol-Disulfide Exchange as a Route for Endosomal Escape of Polymeric Nanoparticles.巯基-二硫键交换作为聚合物纳米颗粒进入内涵体的途径。
Angew Chem Int Ed Engl. 2022 Sep 12;61(37):e202209227. doi: 10.1002/anie.202209227. Epub 2022 Aug 8.
4
ROS-triggered degradable iron-chelating nanogels: Safely improving iron elimination in vivo.ROS 触发型可降解铁螯合纳米胶束：安全改善体内铁清除。
J Control Release. 2018 Aug 10;283:84-93. doi: 10.1016/j.jconrel.2018.05.025. Epub 2018 May 22.
5
Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels.取代基对缩醛和缩酮的 pH 敏感性的影响及其与聚合物纳米凝胶包封稳定性的关系。
J Am Chem Soc. 2017 Feb 15;139(6):2306-2317. doi: 10.1021/jacs.6b11181. Epub 2017 Feb 2.
6
Dual Stimuli - Dual Response Nanoassemblies Prepared from a Simple Homopolymer.由简单均聚物制备的双刺激-双响应纳米组装体。
ACS Macro Lett. 2014 Jan 21;3(1):1-5. doi: 10.1021/mz400515s.
7
Zwitterionic moieties from the Huisgen reaction: a case study with amphiphilic dendritic assemblies.Huisgen 反应中的两性离子部分：两亲树枝状组装体的案例研究。
Chemistry. 2013 Nov 25;19(48):16374-81. doi: 10.1002/chem.201302442. Epub 2013 Oct 22.
本文引用的文献
1
Side-chain peptide-synthetic polymer conjugates via tandem "ester-amide/thiol-ene" post-polymerization modification of poly(pentafluorophenyl methacrylate) obtained using ATRP.通过原子转移自由基聚合（ATRP）得到的聚（五氟苯甲基丙烯酸酯）的串联“酯酰胺/硫醇-烯”后聚合修饰制备侧链肽-合成聚合物缀合物。
Biomacromolecules. 2011 Aug 8;12(8):2908-13. doi: 10.1021/bm200469a. Epub 2011 Jul 7.
2
Multi-responsive copolymers: using thermo-, light- and redox stimuli as three independent inputs towards polymeric information processing.多重响应性共聚物：将热、光和氧化还原刺激作为三个独立的输入，用于聚合物信息处理。
Chem Commun (Camb). 2011 Aug 21;47(31):8859-61. doi: 10.1039/c1cc12652k. Epub 2011 Jun 28.
3
Multistage nanoparticle delivery system for deep penetration into tumor tissue.多阶段纳米颗粒递药系统，用于深入肿瘤组织。
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2426-31. doi: 10.1073/pnas.1018382108. Epub 2011 Jan 18.
4
Self-cross-linked polymer nanogels: a versatile nanoscopic drug delivery platform.自交联聚合物纳米凝胶：一种多功能的纳米级药物递送平台。
J Am Chem Soc. 2010 Dec 8;132(48):17227-35. doi: 10.1021/ja1069932. Epub 2010 Nov 15.
5
Surface-functionalizable polymer nanogels with facile hydrophobic guest encapsulation capabilities.具有易于疏水性客体包封能力的表面功能化聚合物纳米凝胶。
J Am Chem Soc. 2010 Jun 23;132(24):8246-7. doi: 10.1021/ja102316a.
6
Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles.粒径和表面电荷对聚合物纳米粒子细胞摄取和体内分布的影响。
Biomaterials. 2010 May;31(13):3657-66. doi: 10.1016/j.biomaterials.2010.01.065. Epub 2010 Feb 6.
7
Synthesis of hetero-telechelic alpha,omega bio-functionalized polymers.杂臂型α,ω端基生物功能化聚合物的合成。
Biomacromolecules. 2010 Jan 11;11(1):238-44. doi: 10.1021/bm901095j.
8
Impact of nanotechnology on drug delivery.纳米技术对药物递送的影响。
ACS Nano. 2009 Jan 27;3(1):16-20. doi: 10.1021/nn900002m.
9
Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications.缩醛衍生化葡聚糖：一种用于治疗应用的酸响应性可生物降解材料。
J Am Chem Soc. 2008 Aug 13;130(32):10494-5. doi: 10.1021/ja803947s. Epub 2008 Jul 17.
10
Approach to formation of multifunctional polyester particles in controlled nanoscopic dimensions.制备具有可控纳米尺寸的多功能聚酯颗粒的方法。
J Am Chem Soc. 2008 Jul 9;130(27):8706-13. doi: 10.1021/ja711417h. Epub 2008 Jun 11.
Zotero 插件