Misaizu Akane, Kokubo Takeshi, Tazumi Kyoko, Kanayama Masaya, Miura Yutaka
Research Laboratories for Health Science & Food Technologies, Kirin Company Ltd., Yokohama 236-0004, Japan.
Prev Nutr Food Sci. 2014 Dec;19(4):367-72. doi: 10.3746/pnf.2014.19.4.367. Epub 2014 Dec 31.
Caffeine is widely consumed and well known for stimulating the central nervous system. When developing new foods and beverages that contain caffeine, it is important to explore the potential synergistic effects of consuming amino acids and other food ingredients with caffeine on humans. Given the physiological pathways affected by the amino acid ornithine, consumption of ornithine with caffeine may have synergistic effects. The purpose of the present study was to examine the effect of consuming caffeine with ornithine in humans. The study used a randomized, placebo-controlled, double-blinded crossover design. The subjects were all healthy office workers who ingested the placebo, 100 mg caffeine, or 100 mg caffeine plus 200 mg ornithine in the morning and completed questionnaires about their mood. Office workers who consumed the combination of caffeine and ornithine had higher mood ratings 8 h after consumption than office workers who consumed caffeine alone. The results of the present study suggest that there is a unique synergistic effect between caffeine and ornithine on the mood of healthy office workers and that ornithine may potentiate the effects of caffeine.
咖啡因的消费十分广泛，并且因其对中枢神经系统的刺激作用而广为人知。在开发含有咖啡因的新食品和饮料时，探索氨基酸及其他食品成分与咖啡因一同摄入对人体的潜在协同效应非常重要。鉴于氨基酸鸟氨酸会影响生理途径，鸟氨酸与咖啡因一同摄入可能会产生协同效应。本研究的目的是检验在人体中鸟氨酸与咖啡因一同摄入的效果。该研究采用了随机、安慰剂对照、双盲交叉设计。受试者均为健康的上班族，他们在早晨摄入安慰剂、100毫克咖啡因或100毫克咖啡因加200毫克鸟氨酸，并完成关于其情绪的问卷调查。摄入咖啡因和鸟氨酸组合的上班族在摄入8小时后的情绪评分高于单独摄入咖啡因的上班族。本研究结果表明，咖啡因和鸟氨酸对健康上班族的情绪存在独特的协同效应，并且鸟氨酸可能会增强咖啡因的作用。
