Richardson Rachel, Trépel Dominic, Perry Amanda, Ali Shehzad, Duffy Steven, Gabe Rhian, Gilbody Simon, Glanville Julie, Hewitt Catherine, Manea Laura, Palmer Stephen, Wright Barry, McMillan Dean
Department of Health Sciences, University of York, York, UK.
York Health Economics Consortium, York, UK.
Health Technol Assess. 2015 Jan;19(1):1-128. doi: 10.3310/hta19010.
There is policy interest in the screening and treatment of mental health problems in young people who offend, but the value of such screening is not yet known.
To assess the diagnostic test accuracy of screening measures for mental health problems in young people who offend; to evaluate the clinical effectiveness and cost-effectiveness of screening and treatment; to model estimates of cost; to assess the evidence base for screening against UK National Screening Committee criteria; and to identify future research priorities.
In total, 25 electronic databases including MEDLINE, PsycINFO, EMBASE and The Cochrane Library were searched from inception until April 2011. Reverse citation searches of included studies were undertaken and reference list of included studies were examined.
Two reviewers independently examined titles and abstracts and extracted data from included studies using a standardised form. The inclusion criteria for the review were (1) population - young offenders (aged 10-21 years); (2) intervention/instrument - screening instruments for mental health problems, implementation of a screening programme or a psychological or pharmacological intervention as part of a clinical trial; (3) comparator - for diagnostic test accuracy studies, any standardised diagnostic interview; for trials, any comparator; (4) outcomes - details of diagnostic test accuracy, mental health outcomes over the short or longer term or measurement of cost data; and (5) study design - for diagnostic test accuracy studies, any design; for screening programmes, randomised controlled trials or controlled trials; for clinical effectiveness studies, randomised controlled trials; for economic studies, economic evaluations of screening strategies or interventions.
Of 13,580 studies identified, nine, including eight independent samples, met the inclusion criteria for the diagnostic test accuracy and validity of screening measures review. Screening accuracy was typically modest. No studies examined the clinical effectiveness of screening, although 10 studies were identified that examined the clinical effectiveness of interventions for mental health problems. There were too few studies to make firm conclusions about the clinical effectiveness of treatments in this population. No studies met the inclusion criteria for the assessment of the cost-effectiveness of screening or treatment. An exemplar decision model was developed for depression, which identified a number of the likely key drivers of uncertainty, including the prevalence of unidentified mental health problems, the severity of mental health problems and their relationship to generic measures of outcome and the impact of treatment on recidivism. The information evaluated as part of the review was relevant to five of the UK National Screening Committee criteria. On the basis of the above results, none of the five criteria was met.
The conclusions of the review are based on limited evidence. Conclusions are tentative and the decision model should be treated as an exemplar.
Evidence on the clinical effectiveness and cost-effectiveness of screening for mental health problems in young people who offend is currently lacking. Future research should consider feasibility trials of clinical interventions to establish important parameters ahead of conducting definitive trials. Future diagnostic studies should compare the diagnostic test accuracy of a range of screening instruments, including those recommended for use in the UK in this population. These studies should be designed to reduce the decision uncertainty identified by the exemplar decision model.
This study is registered as PROSPERO CRD42011001466.
The National Institute for Health Research Health Technology Assessment programme.
对于违法犯罪青少年心理健康问题的筛查与治疗,政策层面颇为关注,但此类筛查的价值尚不明确。
评估针对违法犯罪青少年心理健康问题筛查措施的诊断测试准确性;评估筛查与治疗的临床有效性及成本效益;对成本进行估算建模;依据英国国家筛查委员会标准评估筛查的证据基础;确定未来研究重点。
截至2011年4月,全面检索了包括MEDLINE、PsycINFO、EMBASE和Cochrane图书馆在内的25个电子数据库。对纳入研究进行反向引文检索,并查阅纳入研究的参考文献列表。
两名综述员独立审查标题和摘要,并使用标准化表格从纳入研究中提取数据。本综述的纳入标准为:(1)研究对象——违法犯罪青少年(年龄10 - 21岁);(2)干预措施/工具——心理健康问题的筛查工具、筛查项目的实施,或作为临床试验一部分的心理或药物干预;(3)对照——对于诊断测试准确性研究,任何标准化诊断访谈;对于试验,任何对照;(4)结局——诊断测试准确性细节、短期或长期心理健康结局,或成本数据测量;(5)研究设计——对于诊断测试准确性研究,任何设计;对于筛查项目,随机对照试验或对照试验;对于临床有效性研究,随机对照试验;对于经济学研究,筛查策略或干预措施的经济学评估。
在检索到的13580项研究中,9项(包括8个独立样本)符合心理健康问题筛查措施诊断测试准确性及有效性综述的纳入标准。筛查准确性通常一般。虽有10项研究对心理健康问题干预措施的临床有效性进行了考察,但尚无研究考察筛查的临床有效性。关于该人群治疗的临床有效性,因研究数量过少难以得出确切结论。没有研究符合筛查或治疗成本效益评估的纳入标准。针对抑郁症开发了一个示例决策模型,该模型确定了一些可能的关键不确定性驱动因素,包括未识别心理健康问题的患病率、心理健康问题的严重程度及其与通用结局指标的关系,以及治疗对再犯的影响。作为综述一部分评估的信息与英国国家筛查委员会的五项标准中的五项相关。基于上述结果,五项标准均未满足。
本综述结论基于有限证据。结论具有试探性,决策模型应视为示例。
目前缺乏关于违法犯罪青少年心理健康问题筛查临床有效性和成本效益的证据。未来研究应考虑进行临床干预可行性试验,以便在开展确定性试验之前确定重要参数。未来诊断研究应比较一系列筛查工具的诊断测试准确性,包括推荐在该人群中使用的英国筛查工具。这些研究应旨在减少示例决策模型所确定的决策不确定性。
本研究在PROSPERO注册,注册号为CRD42011001466。
英国国家卫生研究院卫生技术评估项目。