固定性萎缩后的肌纤维大小和数量
Muscle fibre size and number following immobilisation atrophy.
作者信息
Nicks D K, Beneke W M, Key R M, Timson B F
机构信息
Minority Biomedical Research Support Program, Lincoln University, Jefferson City, Missouri 65109.
出版信息
J Anat. 1989 Apr;163:1-5.
Muscle fibre number and cross sectional area were studied in the response to immobilisation atrophy of the long head of the triceps brachii. Following eight weeks of immobilisation, fibre number of the muscle from the immobilised limb was compared to that of the contralateral control limb in six rats. Mean fibre cross sectional area of the LHT from the immobilised limb was compared to that of the contralateral control for another six animals. Atrophy, as estimated by a decrease in wet muscle weight, was 38.0% for the group used for fibre number estimations and 45.7% for the group used for fibre area. Fibre counts revealed no difference between muscles from immobilised and control limbs. Mean fibre area was 42.1% less for the muscle from the immobilised limb compared to the control limb. The results of this study indicate that atrophy of the LHT produced by immobilisation of the forelimb is the result of atrophy of the muscle fibres without a decrease in muscle fibre number.
研究了肱三头肌长头因固定性萎缩产生的反应中肌纤维数量和横截面积的变化。在六只大鼠中，将固定八周后固定侧肢体肌肉的纤维数量与对侧对照肢体的进行比较。另外六只动物中，将固定侧肢体肱三头肌长头的平均纤维横截面积与对侧对照的进行比较。通过湿肌肉重量的减少来估计萎缩情况，用于纤维数量估计的组萎缩率为38.0%，用于纤维面积估计的组萎缩率为45.7%。纤维计数显示，固定侧和对照侧肢体的肌肉之间没有差异。与对照肢体相比，固定侧肢体肌肉的平均纤维面积减少了42.1%。本研究结果表明，前肢固定导致的肱三头肌长头萎缩是肌纤维萎缩的结果，而肌纤维数量并未减少。
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