Gollnick P D, Timson B F, Moore R L, Riedy M
J Appl Physiol Respir Environ Exerc Physiol. 1981 May;50(5):936-43. doi: 10.1152/jappl.1981.50.5.936.
The effect of muscular enlargement produced by surgical ablation of a synergist and the combination of synergist ablation and exercise on the number of fibers in the soleus (S), plantaris (P), and extensor digitorum longus (EDL) muscles of the rat was studied. The number of fibers per muscle was determined by direct counts of individual fibers dissected from HNO3-treated muscles. Ablation of a synergist produced average enlargements of about 25, 45, and 29% for the S, P, and EDL muscles, respectively. Exercise and synergist ablation produced increases in wet weight to about 44 and 88% for the S and P muscles, respectively, whereas no further increases were observed in the EDL muscles. Intra-animal comparisons revealed that no differences existed for total fiber number or the incidence of fibers with bifurcations between the enlarged and contralateral control muscles. The difference in dry weight of fibers from the enlarged as compared with control muscles was closely correlated to differences in total muscle wet weight. These data demonstrate that hypertrophy rather than hyperplasia was responsible for increases from 10 to over 100% in the weight of skeletal muscles.
研究了通过手术切除协同肌以及协同肌切除与运动相结合所产生的肌肉增大对大鼠比目鱼肌（S）、跖肌（P）和趾长伸肌（EDL）纤维数量的影响。通过直接计数从经硝酸处理的肌肉中分离出的单个纤维来确定每条肌肉的纤维数量。切除协同肌后，比目鱼肌、跖肌和趾长伸肌的平均增大幅度分别约为25%、45%和29%。运动和协同肌切除分别使比目鱼肌和跖肌的湿重增加到约44%和88%，而趾长伸肌未观察到进一步增加。动物体内比较显示，增大的肌肉与对侧对照肌肉之间在总纤维数量或有分叉纤维的发生率方面不存在差异。与对照肌肉相比，增大肌肉的纤维干重差异与总肌肉湿重差异密切相关。这些数据表明，骨骼肌重量从10%增加到超过100%是由肥大而非增生引起的。
