Aguilar-Valles Argel, Inoue Wataru, Rummel Christoph, Luheshi Giamal N
Department of Neuroscience, Université de Montréal and Goodman Cancer Centre, Department of Biochemistry, McGill University, Montréal, Canada.
Robarts Research Institute, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5B7, Canada.
Neuropharmacology. 2015 Sep;96(Pt A):124-34. doi: 10.1016/j.neuropharm.2014.12.023. Epub 2015 Jan 10.
Global levels of obesity are reaching epidemic proportions, leading to a dramatic increase in incidence of secondary diseases and the significant economic burden associated with their treatment. These comorbidities include diabetes, cardiovascular disease, and some psychopathologies, which have been linked to a low-grade inflammatory state. Obese individuals exhibit an increase in circulating inflammatory mediators implicated as the underlying cause of these comorbidities. A number of these molecules are also manufactured and released by white adipose tissue (WAT), in direct proportion to tissue mass and are collectively known as adipokines. In the current review we focused on the role of two of the better-studied members of this family namely, leptin and adiponectin, with particular emphasis on their role in neuro-immune interactions, neuroinflammation and subsequent brain diseases. This article is part of a Special Issue entitled 'Neuroimmunology and Synaptic Function'.
全球肥胖水平正达到流行程度，导致继发性疾病的发病率急剧上升以及与之相关的治疗带来的巨大经济负担。这些合并症包括糖尿病、心血管疾病和一些精神病理学疾病，它们与低度炎症状态有关。肥胖个体循环中的炎症介质增加，这被认为是这些合并症的根本原因。其中许多分子也是由白色脂肪组织（WAT）产生和释放的，与组织质量成正比，统称为脂肪因子。在当前的综述中，我们重点关注了该家族中研究较多的两个成员——瘦素和脂联素的作用，特别强调了它们在神经免疫相互作用、神经炎症及随后的脑部疾病中的作用。本文是名为“神经免疫学与突触功能”的特刊的一部分。
