Mosquera Jesús, Sánchez Mateo I, Mascareñas José L, Eugenio Vázquez M
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Chem Commun (Camb). 2015 Mar 28;51(25):5501-4. doi: 10.1039/c4cc08049a.
We report a light-sensitive histidine building block for Fmoc/tBu solid-phase peptide synthesis in which the imidazole side chain is coordinated to a ruthenium complex. We have applied this building block for the synthesis of caged-histidine peptides that can be readily deprotected by irradiation with visible light, and demonstrated the application of this approach for the photocontrol of the activity of Ni(II)-dependent peptide nucleases.
我们报道了一种用于芴甲氧羰基/叔丁氧羰基（Fmoc/tBu）固相肽合成的光敏感组氨酸构建模块，其中咪唑侧链与钌配合物配位。我们已将此构建模块应用于合成可通过可见光照射轻松脱保护的笼蔽组氨酸肽，并证明了该方法在光控镍（II）依赖性肽核酸酶活性方面的应用。
