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Reversal of drug resistance in Trypanosoma cruzi and Leishmania donovani by verapamil.

作者信息

Neal R A, van Bueren J, McCoy N G, Iwobi M

机构信息

Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, St Albans, Hertfordshire, UK.

出版信息

Trans R Soc Trop Med Hyg. 1989 Mar-Apr;83(2):197-8. doi: 10.1016/0035-9203(89)90642-1.

DOI:10.1016/0035-9203(89)90642-1
PMID:2558433
Abstract

Following previous studies of verapamil reversal of chloroquine resistance in malaria and multi-drug resistance in cancer cells, the effect of verapamil was investigated on nifurtimox-resistant Trypanosoma cruzi in vitro and antimony-resistant Leishmania donovani in vitro and in vivo. Verapamil alone was not active against either parasite, but in combination with nifurtimox it reversed the drug resistance of T. cruzi and in combination with sodium stibogluconate reversed the drug resistance of L. donovani.

摘要

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