Baillie A J, Coombs G H, Dolan T F, Laurie J
J Pharm Pharmacol. 1986 Jul;38(7):502-5. doi: 10.1111/j.2042-7158.1986.tb04623.x.
Liver and serum concentrations of antimony in the mouse have been determined after administration of sodium stibogluconate in the free, liposomal and niosomal form. High liver and low serum values were attained by the use of both vesicular formulations. Niosomal sodium stibogluconate was shown to be more active than free drug against experimental murine visceral leishmaniasis, an effect apparently dependent on maintaining high drug levels in the infected reticuloendothelial system.
在以游离、脂质体和非离子型表面活性剂泡囊形式给予葡糖酸锑钠后，测定了小鼠肝脏和血清中的锑浓度。使用这两种囊泡制剂均能使肝脏中的锑浓度升高，血清中的锑浓度降低。结果表明，非离子型表面活性剂泡囊包裹的葡糖酸锑钠在抗实验性小鼠内脏利什曼病方面比游离药物更具活性，这一效果显然取决于在受感染的网状内皮系统中维持较高的药物水平。
