氟中毒和畸形性骨膜炎作为长期伏立康唑治疗的并发症。
Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment.
作者信息
Rad Babak, Saleem Mohamed, Grant Susan, Florkowski Christopher, Coates Penelope, Gordon David, Rankin Wayne
机构信息
Microbiology & Infectious Diseases, SA Pathology and Flinders Medical Centre, Bedford Park, Australia.
Division of Chemical Pathology, SA Pathology, Adelaide, Australia.
出版信息
Ann Clin Biochem. 2015 Sep;52(Pt 5):611-4. doi: 10.1177/0004563214568873. Epub 2015 Jan 13.
We describe a case of development of painful periostitis deformans in a 39-year-old woman who was receiving long-term voriconazole treatment for Aspergillus infection as a complication of orthotopic liver transplant. Measurement of fluoride levels strongly supports fluorosis to be the mechanism of the voriconazole-induced periostitis deformans and supports the concept that such measurements might be of use in predicting this complication of long-term voriconazole treatment.
我们描述了一名39岁女性的病例，她因原位肝移植并发症感染曲霉菌而接受长期伏立康唑治疗，出现了疼痛性畸形性骨膜炎。氟化物水平的测量有力地支持氟中毒是伏立康唑诱发畸形性骨膜炎的机制，并支持这样的观点，即此类测量可能有助于预测长期伏立康唑治疗的这种并发症。
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