Bakke J E, Feil V J, Zaylskie R G
USDA, ARS, Biosciences Research Laboratory, Fargo, North Dakota 58105.
Biomed Environ Mass Spectrom. 1989 Dec;18(12):1096-8. doi: 10.1002/bms.1200181210.
Methanesulfinic and methanesulfonic acids were shown to be present in urine from rats fed laboratory rat diet. The daily excretions of each acid were equivalent at 0.47 mumol day-1. The excretion of methanesulfinic acid increased about ninefold and that of methanesulfonic doubled when rats were dosed with 17 mumol of pentachlorothioanisole. The excretion of methanesulfinic acid above control levels in urine may be a method for detecting methylthio displacements that occur during the intermediary metabolism of xenobiotics.
结果表明，食用实验室大鼠饲料的大鼠尿液中存在甲亚磺酸和甲磺酸。每种酸的日排泄量相当，均为0.47 μmol/天。当给大鼠投喂17 μmol五氯硫代苯甲醚时，甲亚磺酸的排泄量增加了约9倍，甲磺酸的排泄量增加了一倍。尿液中甲亚磺酸排泄量高于对照水平可能是检测外源化合物中间代谢过程中发生的甲硫基置换的一种方法。
