盐酸甲脒作为一种氨基替代物：I2 催化的芳基甲基酮的氧化氨化反应，生成游离的（N-H）α-酮酰胺。
Formamidine hydrochloride as an amino surrogate: I2-catalyzed oxidative amidation of aryl methyl ketones leading to free (N-H) α-ketoamides.
机构信息
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
出版信息
Org Biomol Chem. 2015 Feb 28;13(8):2239-42. doi: 10.1039/c4ob02591a.
PMID:25587673
Abstract
A highly efficient molecular iodine catalyzed oxidative amidation of aryl methyl ketones with formamidine hydrochloride has been developed. This reaction represents a novel strategy for the synthesis of free (N-H) α-ketoamides. Based on the experimental results, a self-sequenced iodination/Kornblum oxidation/amidation/oxidation/decarbonylation mechanism was proposed.
摘要
一种高效的分子碘催化的芳基甲基酮与盐酸甲脒的氧化酰胺化反应已经被开发出来。该反应代表了一种合成游离（N-H）α-酮酰胺的新策略。根据实验结果，提出了一个自序列碘化/Kornblum 氧化/酰胺化/氧化/脱羰机制。
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