Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Wuhan 430079, P. R. China.
Org Lett. 2014 Jun 6;16(11):2888-91. doi: 10.1021/ol501029w. Epub 2014 May 15.
An iodine-catalyzed oxidative cross-coupling of C-H/N-H has been demonstrated. This simple and efficient approach constructed α-ketoimides in good to excellent yields from methyl ketones and benzamidines hydrochloride under metal-free and peroxide-free conditions. This synthetic strategy was achieved via an in situ iodination-based oxidative coupling pathway.
碘催化的 C-H/N-H 氧化交叉偶联反应已经得到了证明。在无金属和无过氧化物条件下，这种简单高效的方法可以从甲基酮和苯甲脒盐酸盐中得到α-酮亚胺，产率良好到优秀。这种合成策略是通过基于原位碘化的氧化偶联途径实现的。
