Brănişteanu D D, Sauciuc A, Proca B, Fuică A, Gogescu G
Institute for Chemical and Pharmaceutical Research, Iaşi.
Rev Med Chir Soc Med Nat Iasi. 1982 Apr-Jun;86(2):287-94.
While increasing the spontaneous quantal transmitter release in frog neuromuscular junctions, streptomycin blocked the evoked transmitter release by decreasing the quantal content (m). The quantal parameter of release n (number of release sites) was significantly decreased, while p (probability of release through transmitter activation) increased. Streptomycin competes with calcium ions for the membrane release sites while the intracellular mechanisms of release remain unaffected. The data show a good fit to the two-step hypothesis of quantal transmitter release recently developed on the basis of ouabain actions.
