双侧经颅交流电刺激对皮质的抑制和兴奋作用
Cortical inhibition and excitation by bilateral transcranial alternating current stimulation.
作者信息
Cancelli Andrea, Cottone Carlo, Zito Giancarlo, Di Giorgio Marina, Pasqualetti Patrizio, Tecchio Franca
机构信息
Laboratory of Electrophysiology for Translational neuroScience (LET'S) - ISTC - CNR, at Department of Neuroscience, Fatebenefratelli Hospital, Rome, Italy Institute of Neurology, Department of Geriatrics, Neurosciences & Orthopaedics, Catholic University of Sacred Heart, Rome, Italy.
Laboratory of Electrophysiology for Translational neuroScience (LET'S) - ISTC - CNR, at Department of Neuroscience, Fatebenefratelli Hospital, Rome, Italy Department of Neuroscience and Imaging, G. d'Annunzio University of Chieti - Pescara, Italy.
出版信息
Restor Neurol Neurosci. 2015;33(2):105-14. doi: 10.3233/RNN-140411.
PURPOSE
Transcranial electric stimulations (tES) with amplitude-modulated currents are promising tools to enhance neuromodulation effects. It is essential to select the correct cortical targets and inhibitory/excitatory protocols to reverse changes in specific networks. We aimed at assessing the dependence of cortical excitability changes on the current amplitude of 20 Hz transcranial alternating current stimulation (tACS) over the bilateral primary motor cortex.
METHODS
We chose two amplitude ranges of the stimulations, around 25 μA/cm2 and 63 μA/cm2 from peak to peak, with three values (at steps of about 2.5%) around each, to generate, respectively, inhibitory and excitatory effects of the primary motor cortex. We checked such changes online through transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEPs).
RESULTS
Cortical excitability changes depended upon current density (p = 0.001). Low current densities decreased MEP amplitudes (inhibition) while high current densities increased them (excitation).
CONCLUSIONS
tACS targeting bilateral homologous cortical areas can induce online inhibition or excitation as a function of the current density.
目的
采用调幅电流的经颅电刺激（tES）是增强神经调节作用的有前景的工具。选择正确的皮质靶点和抑制/兴奋方案以逆转特定网络的变化至关重要。我们旨在评估双侧初级运动皮质上20赫兹经颅交流电刺激（tACS）的电流幅度对皮质兴奋性变化的依赖性。
方法
我们选择了两个刺激幅度范围，峰峰值约为25μA/cm²和63μA/cm²，每个范围周围有三个值（步长约为2.5%），分别产生初级运动皮质的抑制和兴奋作用。我们通过经颅磁刺激（TMS）诱发的运动诱发电位（MEP）在线检查此类变化。
结果
皮质兴奋性变化取决于电流密度（p = 0.001）。低电流密度降低MEP幅度（抑制），而高电流密度增加MEP幅度（兴奋）。
结论
靶向双侧同源皮质区域的tACS可根据电流密度诱导在线抑制或兴奋。
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