Zhang B
Liaoning Tumor Hospital & Institute, Shenyang.
Zhonghua Zhong Liu Za Zhi. 1989 May;11(3):228-30.
Eighty-one patients with operable breast cancers received the short-term and intensive preoperative chemotherapy, followed by radical mastectomy are presented. The total response rate in the primary tumor to chemotherapy was 59%. Seven patients (8.6%) had complete remission, 41 (50.6%) partial remission and 33 (40.7%) stable lesions. No cancer cells were found histopathologically by serial sections from two primary lesions after chemotherapy. The authors found that tumor with small size, short course and regular shape had a better response rate. Histopathological type, firmness and boundary of tumor, menopausal status, and estrogen receptor (ER) status were not related to the chemotherapeutic effect. No obvious toxicity and side effects were found during the chemotherapy. The chemotherapy did not influence the wound healing. The results indicate that the chemotherapy has a favorable effect on breast cancer and is safe and valid. The response rate of breast cancer to chemotherapy before operation can be used as breast cancer chemosensitivity test in vivo.
本文介绍了81例可手术乳腺癌患者接受短期强化术前化疗后行根治性乳房切除术的情况。原发肿瘤对化疗的总缓解率为59%。7例（8.6%）完全缓解，41例（50.6%）部分缓解，33例（40.7%）病情稳定。化疗后对两个原发灶进行系列切片组织病理学检查未发现癌细胞。作者发现肿瘤体积小、病程短、形态规则者缓解率较好。组织病理学类型、肿瘤质地和边界、绝经状态及雌激素受体（ER）状态与化疗效果无关。化疗期间未发现明显毒性和副作用。化疗不影响伤口愈合。结果表明，化疗对乳腺癌有良好效果，安全有效。乳腺癌术前化疗缓解率可作为体内乳腺癌化疗敏感性试验。
