Pezzoli Matteo, Bona Galvagno Maurizio, Bongioannini Guido
ENT Department, Mauriziano Hospital, Torino, Italy.
BMJ Case Rep. 2015 Jan 14;2015:bcr2014204056. doi: 10.1136/bcr-2014-204056.
We present a case of a woman who developed an oral squamous cell carcinoma (SCC) after being treated for a recurrent ovarian carcinoma with subtotal gastric resection and adjuvant pegylated liposomal doxorubicin (PLD). She received six cycles of PLD induction and maintenance therapy, which was continued for 5 years. She was free from disease at the following visits but 3 years later she developed SCC of her left inferior edentulous gums. The patient was negative for human papillomavirus and had never smoked in her life or had a history of alcohol use or any other environmental risk factors. PLD is known to accumulate in eccrine glands of the hands and the feet and in the oral mucosa, therefore causing skin toxicity and mucositis. It is conceivable that this specific biodistribution to the oral mucosa may be responsible for the onset of SCC.
我们报告一例女性病例，该患者在接受复发性卵巢癌次全胃切除及辅助聚乙二醇化脂质体阿霉素（PLD）治疗后发生口腔鳞状细胞癌（SCC）。她接受了六个周期的PLD诱导和维持治疗，持续了5年。在随后的随访中她无疾病复发，但3年后她左侧下颌无牙牙龈发生了SCC。该患者人乳头瘤病毒检测为阴性，一生中从未吸烟，也无饮酒史或任何其他环境危险因素。已知PLD会在手足的外分泌腺以及口腔黏膜中蓄积，从而导致皮肤毒性和黏膜炎。可以想象，这种在口腔黏膜的特定生物分布可能是SCC发病的原因。
