OCT1 in hepatic steatosis and thiamine disposition.
作者信息
Chen Ligong, Yee Sook Wah, Giacomini Kathleen M
机构信息
a Department of Pharmacology and Pharmaceutical Sciences, School of Medicine , Tsinghua University ; Beijing , China.
出版信息
Cell Cycle. 2015;14(3):283-4. doi: 10.1080/15384101.2015.1006532.
Abstract
摘要
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本文引用的文献
1
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.OCT1 是一种高容量硫胺素转运体，可调节肝脂肪变性，是二甲双胍的作用靶点。
Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8. doi: 10.1073/pnas.1314939111. Epub 2014 Jun 24.
2
Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration.吗啡是有机阳离子转运蛋白 OCT1 的底物，编码 OCT1 基因的多态性影响可待因给药后吗啡的药代动力学。
Biochem Pharmacol. 2013 Sep 1;86(5):666-78. doi: 10.1016/j.bcp.2013.06.019. Epub 2013 Jul 5.
3
Revisiting the mechanisms of metformin action in the liver.重新探讨二甲双胍在肝脏中的作用机制。
Ann Endocrinol (Paris). 2013 May;74(2):123-9. doi: 10.1016/j.ando.2013.03.006. Epub 2013 Apr 10.
4
Human fatty liver disease: old questions and new insights.人类脂肪肝疾病：旧问题与新见解。
Science. 2011 Jun 24;332(6037):1519-23. doi: 10.1126/science.1204265.
5
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.二甲双胍通过降低肝内能量状态，独立于 LKB1/AMPK 途径抑制小鼠的肝糖异生。
J Clin Invest. 2010 Jul;120(7):2355-69. doi: 10.1172/JCI40671. Epub 2010 Jun 23.
6
Cloning and functional expression of a human liver organic cation transporter.一种人类肝脏有机阳离子转运体的克隆与功能表达
Mol Pharmacol. 1997 Jun;51(6):913-21. doi: 10.1124/mol.51.6.913.
7
Metabolic heterogeneity of hepatocytes across the liver acinus.肝腺泡内肝细胞的代谢异质性。
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