大剂量硫胺素与特发性震颤
High-dose thiamine and essential tremor.
作者信息
Costantini Antonio
机构信息
Department of Neurology, Villa Immacolata, Viterbo, Italy.
出版信息
BMJ Case Rep. 2018 Mar 30;2018:bcr-2017-223945. doi: 10.1136/bcr-2017-223945.
Abstract
Essential tremor is a common neurological disease. The medical treatment of this affection currently involves the use of propranolol, primidone and other drugs. These drugs, however, are often not effective in reducing tremor and cause side effects in a large share of the patients treated. The treatment with intramuscular high-dose thiamine has led to a rapid, remarkable and persistent improvement of the symptoms in two patients with essential tremor. This result suggests the possibility that high doses of intramuscular thiamine may be an affordable alternative, highly effective and long-lasting medical treatment that has shown no relevant side effect.
摘要
特发性震颤是一种常见的神经系统疾病。目前对这种疾病的医学治疗包括使用普萘洛尔、扑米酮和其他药物。然而，这些药物在减轻震颤方面往往效果不佳，并且在很大一部分接受治疗的患者中会引起副作用。对两名特发性震颤患者进行肌肉注射大剂量硫胺素的治疗后，症状迅速、显著且持续改善。这一结果表明，大剂量肌肉注射硫胺素可能是一种经济实惠、高效且持久的医学治疗方法，且未显示出相关副作用。
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