Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.
Science. 2011 Jun 24;332(6037):1519-23. doi: 10.1126/science.1204265.
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries. The disease begins with the aberrant accumulation of triglyceride in the liver, which in some individuals elicits an inflammatory response that can progress to cirrhosis and liver cancer. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood, and therapeutic options are limited. Here, we discuss recent mechanistic insights into NAFLD, focusing primarily on those that have emerged from human genetic and metabolic studies.
非酒精性脂肪性肝病（NAFLD）是一个迅速增长的健康问题，影响着发达国家三分之一的成年人和越来越多的儿童。该疾病始于肝内甘油三酯的异常蓄积，在某些个体中会引发炎症反应，进而进展为肝硬化和肝癌。尽管 NAFLD 与肥胖和胰岛素抵抗密切相关，但它的发病机制仍不清楚，治疗选择也很有限。在这里，我们讨论了最近对 NAFLD 的机制见解，主要集中在那些从人类遗传和代谢研究中出现的见解。
