Reid A F, Coghlan J P, Spence C D, Whitworth J A, Scoggins B A
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Australia.
J Steroid Biochem. 1989 Dec;33(6):1213-21. doi: 10.1016/0022-4731(89)90432-9.
This study investigated the anti-mineralocorticoid potency and haemodynamic effects of a series of mineralocorticoid antagonists of the spirolactone type (RU 28318, spironolactone, K-prorenoate, K-canrenoate and canrenone), for their ability to prevent the development of ACTH-induced hypertension in conscious sheep. In vivo bioassay, using aldosterone dependent changes in parotid salivary [Na+]/[K+] of sodium depleted adrenalectomized sheep, showed spironolactone was the most potent anti-mineralocorticoid tested. Infusions of the antagonists at equal doses alone for 4 days demonstrated that none affected mean arterial pressure, except for K-prorenoate which exhibited slight pressor activity. All the antagonists produced a natriuresis. Some of the steroid antagonists of the spirolactone group blocked the development of ACTH hypertension in sheep, spironolactone being the most effective. This study provides additional evidence for an essential mineralocorticoid component in ACTH-induced hypertension.
本研究调查了一系列螺内酯类盐皮质激素拮抗剂（RU 28318、螺内酯、丙酸睾酮、坎利酸钾和坎利酮）的抗盐皮质激素效力和血流动力学效应，以评估它们预防促肾上腺皮质激素（ACTH）诱导的清醒绵羊高血压的能力。在体内生物测定中，利用钠耗竭的肾上腺切除绵羊腮腺唾液中[Na+]/[K+]的醛固酮依赖性变化，结果显示螺内酯是所测试的最有效的抗盐皮质激素。以等剂量单独输注拮抗剂4天表明，除了表现出轻微升压活性的丙酸睾酮外，其他拮抗剂均不影响平均动脉压。所有拮抗剂均产生利钠作用。螺内酯组的一些甾体拮抗剂可阻止绵羊ACTH高血压的发展，其中螺内酯最为有效。本研究为ACTH诱导的高血压中存在必需的盐皮质激素成分提供了额外证据。
