Mills E H, Coghlan J P, Denton D A, Nelson M A, Spence C D, Whitworth J A, Scoggins B A
Clin Exp Hypertens A. 1984;6(9):1613-24. doi: 10.3109/10641968409044073.
This study examines the blood pressure and electrolyte response to adrenocorticotrophic hormone (ACTH) in K loaded sheep to test the hypothesis that ACTH-induced hypertension is blunted in K loaded sheep. ACTH treatment in sheep on a 'normal' Na (70-100 mmol/day) and high K intake (congruent to 800 mmol/day) increased mean arterial pressure (MAP) by upto 17 mmHg over 5 days. Cardiac rate and urinary Na excretion also increased. Plasma [Na] and [K] fell with ACTH. On a lower Na (30 mmol/day) and high K intake (congruent to 800 mmol/day) ACTH raised MAP by upto 16 mmHg over 5 days. Cardiac rate, urinary Na and K excretion also increased. Plasma [Na] fell and plasma [K] was unchanged. Thus, ACTH hypertension is not modified in chronically K loaded sheep, although electrolyte responses are different from normal.
本研究检测了钾负荷绵羊对促肾上腺皮质激素（ACTH）的血压和电解质反应，以验证钾负荷绵羊中ACTH诱导的高血压减弱这一假说。对摄入“正常”钠（70 - 100 mmol/天）和高钾（约800 mmol/天）的绵羊进行ACTH治疗，5天内平均动脉压（MAP）升高高达17 mmHg。心率和尿钠排泄也增加。ACTH作用下血浆[Na]和[K]下降。在较低钠（30 mmol/天）和高钾摄入（约800 mmol/天）情况下，ACTH在5天内使MAP升高高达16 mmHg。心率、尿钠和钾排泄也增加。血浆[Na]下降而血浆[K]无变化。因此，尽管电解质反应与正常情况不同，但在长期钾负荷绵羊中ACTH高血压并未改变。
