Savalli Giorgia, Bashir Zafar I, Warburton E Clea
Departments of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Department of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom.
Learn Mem. 2015 Jan 15;22(2):69-73. doi: 10.1101/lm.036921.114. Print 2015 Feb.
Object-in-place (OiP) memory is critical for remembering the location in which an object was last encountered and depends conjointly on the medial prefrontal cortex, perirhinal cortex, and hippocampus. Here we examined the role of dopamine D1/D5 receptor neurotransmission within these brain regions for OiP memory. Bilateral infusion of D1/D5 receptor antagonists SCH23390 or SKF83566 into the medial prefrontal cortex, prior to memory acquisition, impaired OiP performance following a 5 min or 1 h delay. Retrieval was unaffected. Intraperirhinal or intrahippocampal infusions of SCH23390 had no effect. These results reveal a selective role for D1/D5 receptors in the mPFC during OiP memory encoding.
物体定位（OiP）记忆对于记住物体上次出现的位置至关重要，并且共同依赖于内侧前额叶皮质、嗅周皮质和海马体。在这里，我们研究了这些脑区内多巴胺D1/D5受体神经传递在OiP记忆中的作用。在记忆获取之前，将D1/D5受体拮抗剂SCH23390或SKF83566双侧注入内侧前额叶皮质，在延迟5分钟或1小时后，OiP表现受损。检索不受影响。向嗅周皮质内或海马体内注入SCH23390没有效果。这些结果揭示了D1/D5受体在OiP记忆编码过程中在内侧前额叶皮质中的选择性作用。
