Pasquali Livia, Lucchesi Cinzia, Pecori Chiara, Metelli Maria Rita, Pellegrini Silvia, Iudice Alfonso, Bonuccelli Ubaldo
Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Italy.
Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Italy.
J Neuroimmunol. 2015 Jan 15;278:53-9. doi: 10.1016/j.jneuroim.2014.12.005. Epub 2014 Dec 5.
The main aim of the study was to evaluate levels of cytokines IL-1ra, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, TNF-alfa, TGB-beta1 and IFN-gamma in 30 patients with relapsing remitting (RRMS) compared to 30 secondary progressive multiple sclerosis (SPMS) in a peripheral blood sample. Statistical analysis showed significant higher levels of IL-17 and INF-gamma, which are cytokines with pro-inflammatory properties, and lower levels of TGF-beta1, a molecule with immunosuppressant activity, in RRMS compared to SPMS. These results underline the existence of a different cytokines dysregulation in RRMS compared to SPMS phases with higher pro-inflammatory activity in RRMS.
该研究的主要目的是评估30例复发缓解型多发性硬化症（RRMS）患者与30例继发进展型多发性硬化症（SPMS）患者外周血样本中细胞因子IL-1ra、IL-2、IL-4、IL-6、IL-8、IL-10、IL-12、IL-17、肿瘤坏死因子-α（TNF-α）、转化生长因子-β1（TGF-β1）和干扰素-γ（IFN-γ）的水平。统计分析显示，与SPMS相比，RRMS中具有促炎特性的细胞因子IL-17和IFN-γ水平显著更高，而具有免疫抑制活性的分子TGF-β1水平更低。这些结果强调，与SPMS阶段相比，RRMS存在不同的细胞因子失调，RRMS具有更高的促炎活性。
