Korporal-Kuhnke Mirjam, Haas Jürgen, Schwarz Alexander, Jarius Sven, Wildemann Brigitte
Molecular Neuroimmunology, Department of Neurology, University Hospital Heidelberg, Germany.
Molecular Neuroimmunology, Department of Neurology, University Hospital Heidelberg, Germany.
J Neuroimmunol. 2015 Jan 15;278:60-8. doi: 10.1016/j.jneuroim.2014.11.012. Epub 2014 Nov 22.
B cells and antibodies are thought to be relevant in chronic immune neuropathies (CIN). We analysed peripheral B-cell homeostasis and effects of high-dose intravenous immunoglobulin (IVIg) on B-cell phenotypes in patients with multifocal motor neuropathy (n=22) and chronic inflammatory demyelinating polyneuropathy (n=8) by multi-color flow cytometry. At baseline, total B-cell numbers were decreased, but mature plasma cells were markedly elevated. IVIg rapidly prompted a decrease in plasma cell numbers and left B-cell homeostasis unchanged. Thus, expanded frequencies of plasma cells might be involved in CIN immunopathogenesis and are downscaled after clinically successful IVIg administration.
B细胞和抗体被认为与慢性免疫性神经病（CIN）有关。我们通过多色流式细胞术分析了多灶性运动神经病患者（n = 22）和慢性炎症性脱髓鞘性多发性神经病患者（n = 8）的外周B细胞稳态以及高剂量静脉注射免疫球蛋白（IVIg）对B细胞表型的影响。在基线时，总B细胞数量减少，但成熟浆细胞明显升高。IVIg迅速促使浆细胞数量减少，而B细胞稳态保持不变。因此，浆细胞频率的增加可能参与了CIN的免疫发病机制，并且在IVIg临床治疗成功后会降低。
