Klehmet Juliane, Staudt Max, Ulm Lena, Unterwalder Nadine, Meisel Andreas, Meisel Christian
Department of Neurology, Charité Universitaetsmedizin, Charitéplatz 1, Berlin, Germany.
Department of Immunology, Labor Berlin Charité Vivantes, Sylter Strasse 2, Berlin, Germany.
J Neuroimmunol. 2015 Jun 15;283:17-22. doi: 10.1016/j.jneuroim.2015.03.023. Epub 2015 Apr 7.
The present study compared lymphocyte and T memory subsets in currently untreated patients with chronic inflammatory demyelinating polyneuropathy (CIDP) to glucocorticosteroid (GS) and intravenous immunoglobulin (IVIG) treated patients. Peripheral blood from 48 CIDP patients (21 untreated who were either treatment naïve or without treatment during the last 3 months, 17 IVIG and 10 GS treatment) and from 12 age-matched controls was evaluated using flow cytometric analysis. Our data demonstrate that long-term GS treatment is associated with reduced frequencies of total CD4+ T cells, CD4+ memory subsets and NK cells while long-term IVIG treatment is associated with alterations of the CD8+ memory compartment. Reduction of CD4+ naïve T cell counts may explain the observation that GS treatment induces prolonged clinical remission compared to IVIG treatment.
本研究比较了慢性炎性脱髓鞘性多发性神经病（CIDP）目前未治疗患者与糖皮质激素（GS）及静脉注射免疫球蛋白（IVIG）治疗患者的淋巴细胞和T记忆亚群。使用流式细胞术分析评估了48例CIDP患者（21例未治疗患者，包括初治患者或过去3个月内未接受治疗的患者、17例接受IVIG治疗的患者和10例接受GS治疗的患者）以及12例年龄匹配对照者的外周血。我们的数据表明，长期GS治疗与总CD4+T细胞、CD4+记忆亚群及自然杀伤（NK）细胞频率降低有关，而长期IVIG治疗与CD8+记忆区室改变有关。CD4+初始T细胞计数减少可能解释了与IVIG治疗相比，GS治疗可诱导更长时间临床缓解这一观察结果。
