Gao Liang, Nie Kun, Tang Hongmei, Wang Limin, Zhao Jiehao, Gan Rong, Huang Jing, Feng Shujun, Zhu Ruiming, Duan Zhenpeng, Zhang Yuhu, Wang Lijuan
Southern Medical University, Guangzhou, China; Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Road II, Guangzhou, Guangdong Province 510080, China.
Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Road II, Guangzhou, Guangdong Province 510080, China.
J Clin Neurosci. 2015 Mar;22(3):488-92. doi: 10.1016/j.jocn.2014.08.032. Epub 2015 Jan 13.
To investigate sex differences in cognitive function in Parkinson's disease patients, a cohort of 172 male patients and 139 female patients were recruited for this study. Their demographic and clinical features, including age, disease duration, education level, Unified Parkinson's Disease Rating Scale-III, Hoehn-Yahr Scale, activities of daily living, Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale score were recorded. The Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Wechsler Adult Intelligence Scale-Chinese Revision (WAIS-RC) and Wechsler Memory Scale-Chinese Revision (WMS-RC) scores were compared to distinguish the cognitive properties between the two groups. The MMSE values did not show a significant difference between the groups. However, the MoCA scores of male patients were significantly higher than those of female patients (adjusted p<0.05). The male group demonstrated better performances with respect to visuospatial function, naming and abstraction (adjusted p<0.05). The WAIS-RC data showed that female patients had lower scores in information, vocabulary, picture completion, block design and picture arrangement (adjusted p<0.05), and the WMS-RC data showed that 100-1 and cumulative addition abilities were significantly weaker in females than males (adjusted p<0.05). Cognitive disturbances were more prevalent and severe in women among Chinese Parkinson's disease patients.
为研究帕金森病患者认知功能的性别差异，本研究招募了172例男性患者和139例女性患者。记录了他们的人口统计学和临床特征，包括年龄、病程、教育程度、统一帕金森病评定量表-III、霍恩-亚尔分级量表、日常生活活动能力、汉密尔顿抑郁评定量表和汉密尔顿焦虑评定量表评分。比较简易精神状态检查表（MMSE）、蒙特利尔认知评估量表（MoCA）、韦氏成人智力量表-中国修订版（WAIS-RC）和韦氏记忆量表-中国修订版（WMS-RC）评分，以区分两组之间的认知特性。两组间MMSE值无显著差异。然而，男性患者的MoCA评分显著高于女性患者（校正p<0.05）。男性组在视觉空间功能、命名和抽象方面表现更好（校正p<0.05）。WAIS-RC数据显示，女性患者在知识、词汇、图片填充、积木图案和图片排列方面得分较低（校正p<0.05），WMS-RC数据显示，女性的100-1和连加能力明显弱于男性（校正p<0.05）。在中国帕金森病患者中，女性认知障碍更为普遍和严重。
